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MedKoo Cat#: 575523 | Name: Floxacillin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Floxacillin is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible Gram-positive bacteria.

Chemical Structure

Floxacillin
Floxacillin
CAS#5250-39-5 (free acid)

Theoretical Analysis

MedKoo Cat#: 575523

Name: Floxacillin

CAS#: 5250-39-5 (free acid)

Chemical Formula: C19H17ClFN3O5S

Exact Mass: 453.0561

Molecular Weight: 453.87

Elemental Analysis: C, 50.28; H, 3.78; Cl, 7.81; F, 4.19; N, 9.26; O, 17.63; S, 7.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
5250-39-5 (free acid) 40182-54-5 (magnesium) 1847-24-1 (sodium) 34214-51-2 (sodium hydrate)
Synonym
Floxacillin; Floxapen; Flucloxacillin; flucloxacilina; Flucloxacilline; Flucloxacillinum; BRL 2039; BRL2039; BRL-2039
IUPAC/Chemical Name
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S(2alpha,5alpha,6beta))
InChi Key
UIOFUWFRIANQPC-JKIFEVAISA-N
InChi Code
InChI=1S/C19H17ClFN3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1
SMILES Code
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=C(F)C=CC=C4Cl)=O)N1C2=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 453.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: van Hattem S, Beerthuizen GI, Kardaun SH. Severe flucloxacillin-induced acute generalized exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature. Br J Dermatol. 2014 Dec;171(6):1539-45. doi: 10.1111/bjd.13152. Epub 2014 Nov 9. Review. PubMed PMID: 24888401. 2: Quirke M, O'Sullivan R, McCabe A, Ahmed J, Wakai A. Are two penicillins better than one? A systematic review of oral flucloxacillin and penicillin V versus oral flucloxacillin alone for the emergency department treatment of cellulitis. Eur J Emerg Med. 2014 Jun;21(3):170-4. doi: 10.1097/MEJ.0b013e328360d980. Review. PubMed PMID: 23542420. 3: Xu B, Murray M. Flucloxacillin induced acute renal failure. Aust Fam Physician. 2008 Dec;37(12):1009-11. Review. PubMed PMID: 19142275. 4: McNeil JJ, Grabsch EA, McDonald MM. Postmarketing surveillance: strengths and limitations. The flucloxacillin-dicloxacillin story. Med J Aust. 1999 Mar 15;170(6):270-3. Review. PubMed PMID: 10212650. 5: Koek GH, Stricker BH, Blok AP, Schalm SW, Desmet VJ. Flucloxacillin-associated hepatic injury. Liver. 1994 Oct;14(5):225-9. Review. PubMed PMID: 7997079.

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