Chelerythrine hydrochloride | CAS# 3895-92-9 (HCl)

MedKoo Cat#: 412810 | Name: Chelerythrine chloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chelerythrine hydrochloride is the salt form of chelerythrine, a benzophenanthridine alkaloid present in the plant Chelidonium majus (greater celandine). It is a potent, selective, and cell-permeable protein kinase C inhibitor in vitro. And an efficacious antagonist of G-protein-coupled CB1 receptors. This molecule also exhibits anticancer qualities and it has served as a base for many potential novel drugs against cancer.

Chemical Structure

Chelerythrine chloride

CAS#3895-92-9 (chloride)

Theoretical Analysis

MedKoo Cat#: 412810

Name: Chelerythrine chloride

CAS#: 3895-92-9 (chloride)

Chemical Formula: C21H18ClNO4

Exact Mass: 383.0924

Molecular Weight: 383.83

Elemental Analysis: C, 65.71; H, 4.73; Cl, 9.24; N, 3.65; O, 16.67

Price and Availability

Size	Price	Availability
25mg	USD 450.00	2 Weeks
100mg	USD 950.00	2 Weeks
250mg	USD 1,650.00	2 Weeks

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Related CAS #

478-03-5 (hydroxide) 3895-92-9 (chloride) 34316-15-9 (cation)

Synonym

Chelerythrine chloride; Broussonpapyrine chloride; NSC36405; NSC-36405; NSC 36405

IUPAC/Chemical Name

(1,3)Benzodioxolo(5,6-c)phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride (9CI)

InChi Key

WEEFNMFMNMASJY-UHFFFAOYSA-M

InChi Code

InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1

SMILES Code

C[N+]1=CC2=C(OC)C(OC)=CC=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5.[Cl-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 383.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yang T, Xu R, Su Q, Wang H, Liu F, Dai B, Wang B, Zhang Y. Chelerythrine hydrochloride inhibits proliferation and induces mitochondrial apoptosis in cervical cancer cells via PI3K/BAD signaling pathway. Toxicol In Vitro. 2020 Oct;68:104965. doi: 10.1016/j.tiv.2020.104965. Epub 2020 Aug 11. PMID: 32791301. 2: Ok SH, Kwon SC, Baik J, Hong JM, Oh J, Han JY, Sohn JT. Dexmedetomidine- Induced Contraction Involves CPI-17 Phosphorylation in Isolated Rat Aortas. Int J Mol Sci. 2016 Sep 30;17(10):1663. doi: 10.3390/ijms17101663. PMID: 27706026; PMCID: PMC5085696. 3: Akhvlediani L, Koiava T, Lomtadze L, Joxadze M, Msxiladze L, Berashvili D, Bakuridze A. [COMPARATIVE ANALYSIS OF ANTIBACTERIAL EFFECT OF PHYTOANTIBIOTICS AND ANTIBIOTICS]. Georgian Med News. 2016 Nov;(Issue):79-86. Russian. PMID: 28009321. 4: Yang N, Yue R, Ma J, Li W, Zhao Z, Li H, Shen Y, Hu Z, Lv C, Xu X, Yang Y, Dai X, Liu X, Yu Y, Zhang W. Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production. Pharmacol Res. 2019 Oct;148:104368. doi: 10.1016/j.phrs.2019.104368. Epub 2019 Aug 12. Erratum in: Pharmacol Res. 2020 Jan 14;:104624. PMID: 31415918. 5: Fatehi-Hassanabad Z, Imen-Shahidi M, Fatehi M, Farrokhfall K, Parsaeei H. The beneficial in vitro effects of lovastatin and chelerythrine on relaxatory response to acetylcholine in the perfused mesentric bed isolated from diabetic rats. Eur J Pharmacol. 2006 Mar 27;535(1-3):228-33. doi: 10.1016/j.ejphar.2006.01.063. Epub 2006 Mar 3. PMID: 16516190. 6: Dal-Cim T, Poluceno GG, Lanznaster D, de Oliveira KA, Nedel CB, Tasca CI. Guanosine prevents oxidative damage and glutamate uptake impairment induced by oxygen/glucose deprivation in cortical astrocyte cultures: involvement of A1 and A2A adenosine receptors and PI3K, MEK, and PKC pathways. Purinergic Signal. 2019 Dec;15(4):465-476. doi: 10.1007/s11302-019-09679-w. Epub 2019 Sep 13. PMID: 31520282; PMCID: PMC6923312. 7: Yu J, Ok SH, Kim WH, Cho H, Park J, Shin IW, Lee HK, Chung YK, Choi MJ, Kwon SC, Sohn JT. Dexmedetomidine-Induced Contraction in the Isolated Endothelium- Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation. Int J Med Sci. 2015 Sep 4;12(9):727-36. doi: 10.7150/ijms.11952. PMID: 26392810; PMCID: PMC4571550. 8: He M, Yang Z, Zhang L, Song C, Li Y, Zhang X. Additive effects of cherlerythrine chloride combination with erlotinib in human non-small cell lung cancer cells. PLoS One. 2017 Apr 11;12(4):e0175466. doi: 10.1371/journal.pone.0175466. PMID: 28399187; PMCID: PMC5388488. 9: Wu MJ, Shin DH, Kim MY, Park CG, Kim YD, Lee J, Park IK, Choi S, So I, Park JS, Jun JY. Functional effects of β3-adrenoceptor on pacemaker activity in interstitial cells of Cajal from the mouse colon. Eur J Pharmacol. 2015 May 5;754:32-40. doi: 10.1016/j.ejphar.2015.02.031. Epub 2015 Feb 25. PMID: 25725113. 10: Kurowski P, Gawlak M, Szulczyk P. Muscarinic receptor control of pyramidal neuron membrane potential in the medial prefrontal cortex (mPFC) in rats. Neuroscience. 2015 Sep 10;303:474-88. doi: 10.1016/j.neuroscience.2015.07.023. Epub 2015 Jul 14. PMID: 26186898.