MedKoo Cat#: 575476 | Name: FK-838

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FK-838 is an adenosine subtype-1 receptor antagonist.

Chemical Structure

FK-838
FK-838
CAS#131185-37-0

Theoretical Analysis

MedKoo Cat#: 575476

Name: FK-838

CAS#: 131185-37-0

Chemical Formula: C21H18N4O3

Exact Mass: 374.1379

Molecular Weight: 374.40

Elemental Analysis: C, 67.37; H, 4.85; N, 14.96; O, 12.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
FK 838; FK838; FK-838
IUPAC/Chemical Name
1(6H)-Pyridazinebutanoic acid, 6-oxo-3-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-
InChi Key
FKJPZJACCBMNKZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H18N4O3/c26-18-12-11-16(22-25(18)14-6-10-19(27)28)20-17-9-4-5-13-24(17)23-21(20)15-7-2-1-3-8-15/h1-5,7-9,11-13H,6,10,14H2,(H,27,28)
SMILES Code
OC(=O)CCCN1N=C(C=CC1=O)c2c(nn3ccccc23)c4ccccc4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 374.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Uehara Y, Numabe A, Hirawa N, Kawabata Y, Nagoshi H, Kaneko H, Gomi T, Goto A, Toyo-oka T, Omata M. A new adenosine subtype-1 receptor antagonist, FK-838, attenuates salt-induced hypertension in Dahl salt-sensitive rats. Am J Hypertens. 1995 Dec;8(12 Pt 1):1189-99. doi: 10.1016/0895-7061(95)00253-7. PMID: 8998253. 2. Bak M, Thomsen K. Effects of the adenosine A1 receptor inhibitor FK 838 on proximal tubular fluid output in rats. Nephrol Dial Transplant. 2004 May;19(5):1077-82. doi: 10.1093/ndt/gfh097. Epub 2004 Feb 19. PMID: 14993484.