Synonym
FK 156; FK156; FK-156
IUPAC/Chemical Name
(5R,13S,16R)-5-((R)-4-amino-4-carboxybutyl)-10-carboxy-16-hydroxy-13-methyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecanoic acid
InChi Key
RNZKYQHTFUFVSS-ZLUZDFLPSA-N
InChi Code
InChI=1S/C20H33N5O11/c1-9(23-17(31)10(2)26)16(30)25-13(20(35)36)6-7-14(27)24-12(18(32)22-8-15(28)29)5-3-4-11(21)19(33)34/h9-13,26H,3-8,21H2,1-2H3,(H,22,32)(H,23,31)(H,24,27)(H,25,30)(H,28,29)(H,33,34)(H,35,36)/t9-,10+,11+,12+,13?/m0/s1
SMILES Code
C[C@@H](O)C(=O)N[C@@H](C)C(=O)NC(CCC(=O)N[C@H](CCC[C@@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
519.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Mine Y, Yokota Y, Wakai Y, Fukada S, Nishida M, Goto S, Kuwahara S. Immunoactive peptides, FK-156 and FK-565. I. Enhancement of host resistance to microbial infection in mice. J Antibiot (Tokyo). 1983 Aug;36(8):1045-50. doi: 10.7164/antibiotics.36.1045. PMID: 6415029.
2. Yokota Y, Mine Y, Wakai Y, Watanabe Y, Nishida M, Goto S, Kuwahara S. Immunoactive peptides, FK-156 and FK-565. II. Restoration of host resistance to microbial infection in immunosuppressed mice. J Antibiot (Tokyo). 1983 Aug;36(8):1051-8. doi: 10.7164/antibiotics.36.1051. PMID: 6415030.
3. Izumi S, Nakahara K, Gotoh T, Hashimoto S, Kino T, Okuhara M, Aoki H, Imanaka H. Antitumor effects of novel immunoactive peptides, FK-156 and its synthetic derivatives. J Antibiot (Tokyo). 1983 May;36(5):566-74. doi: 10.7164/antibiotics.36.566. PMID: 6192122.
