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MedKoo Cat#: 463658 | Name: ER272

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ER272 is a natural PKC activator, inducing hippocampal neurogenesis.

Chemical Structure

ER272
ER272
CAS#25090-74-8

Theoretical Analysis

MedKoo Cat#: 463658

Name: ER272

CAS#: 25090-74-8

Chemical Formula: C24H34O6

Exact Mass: 418.2355

Molecular Weight: 418.53

Elemental Analysis: C, 68.88; H, 8.19; O, 22.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ER272; ER 272; ER-272; 12-Deoxyphorbol 13-isobutyrate;
IUPAC/Chemical Name
(1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl isobutyrate
InChi Key
QSTFRCUXCBXJAW-CYZOKXGXSA-N
InChi Code
InChI=1S/C24H34O6/c1-12(2)20(27)30-23-9-14(4)24(29)16(18(23)21(23,5)6)8-15(11-25)10-22(28)17(24)7-13(3)19(22)26/h7-8,12,14,16-18,25,28-29H,9-11H2,1-6H3/t14-,16+,17-,18-,22-,23+,24-/m1/s1
SMILES Code
C[C@H](C[C@]1(OC(C(C)C)=O)[C@H]2C1(C)C)[C@@]3(O)[C@H]2C=C(CO)C[C@@]4(O)[C@H]3C=C(C)C4=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 418.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Domínguez-García S, Gómez-Oliva R, Geribaldi-Doldán N, Hierro-Bujalance C, Sendra M, Ruiz FA, Carrascal L, Macías-Sánchez AJ, Verástegui C, Hernández-Galán R, García-Alloza M, Nunez-Abades P, Castro C. Effects of classical PKC activation on hippocampal neurogenesis and cognitive performance: mechanism of action. Neuropsychopharmacology. 2020 Dec 17. doi: 10.1038/s41386-020-00934-y. Epub ahead of print. PMID: 33335309.