MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 535783 | Name: Dopastin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dopastin is a mushroom extract.

Chemical Structure

Dopastin
Dopastin
CAS#37134-80-8

Theoretical Analysis

MedKoo Cat#: 535783

Name: Dopastin

CAS#: 37134-80-8

Chemical Formula: C9H17N3O3

Exact Mass: 215.1270

Molecular Weight: 215.25

Elemental Analysis: C, 50.22; H, 7.96; N, 19.52; O, 22.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Dopastin
IUPAC/Chemical Name
2-Butenamide, N-(2-(hydroxynitrosoamino)-3-methylbutyl)-, (S-(E))-
InChi Key
FJUBKTNNXRFHFD-WTSVBCDHSA-N
InChi Code
InChI=1S/C9H17N3O3/c1-4-5-9(13)10-6-8(7(2)3)12(15)11-14/h4-5,7-8,15H,6H2,1-3H3,(H,10,13)/b5-4+/t8-/m1/s1
SMILES Code
C/C=C/C(NC[C@@H](N(O)N=O)C(C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 215.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Iimura H, Takeuchi T, Kondo S, Matsuzaki M, Umezawa H. Dopastin, an inhibitor of dopamine -hydroxylase. J Antibiot (Tokyo). 1972 Aug;25(8):497-500. doi: 10.7164/antibiotics.25.497. PMID: 4648494. 2: Stadler M, Monticelli S, Seidel T, Luger D, Salzer I, Boehm S, Holzer W, Schwarzer C, Urban E, Khom S, Langer T, Pace V, Hering S. Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABAA) Receptor Modulators. J Med Chem. 2019 Jan 10;62(1):317-341. doi: 10.1021/acs.jmedchem.8b00859. Epub 2018 Oct 23. PMID: 30289721. 3: Shiino M, Watanabe Y, Umezawa K. Synthesis of N-substituted N-nitrosohydroxylamines as inhibitors of mushroom tyrosinase. Bioorg Med Chem. 2001 May;9(5):1233-40. doi: 10.1016/s0968-0896(01)00003-7. PMID: 11377181. 4: Stadler RH, Verzegnassi L, Varga N, Grigorov M, Studer A, Riediker S, Schilter B. Formation of vinylogous compounds in model Maillard reaction systems. Chem Res Toxicol. 2003 Oct;16(10):1242-50. doi: 10.1021/tx034088g. PMID: 14565766. 5: Magenheimer BS, St John PL, Isom KS, Abrahamson DR, De Lisle RC, Wallace DP, Maser RL, Grantham JJ, Calvet JP. Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter- dependent cystic dilation. J Am Soc Nephrol. 2006 Dec;17(12):3424-37. doi: 10.1681/ASN.2006030295. Epub 2006 Nov 15. PMID: 17108316. 6: Yuan Y, Bai L, Nan J, Liu J, Luan X. Regiospecific Ficini [2 + 2] cycloaddition of ynamides with cyclic isoimidium salts under catalyst-free conditions. Org Lett. 2014 Aug 15;16(16):4316-9. doi: 10.1021/ol5020587. Epub 2014 Aug 7. PMID: 25102092. 7: Xu XD, Zhang XZ, Wang B, Cheng SX, Zhuo RX, Wang ZC. Fabrication of a novel temperature sensitive poly(N-isopropyl-3-butenamide) hydrogel. Colloids Surf B Biointerfaces. 2007 Oct 1;59(2):158-63. doi: 10.1016/j.colsurfb.2007.05.005. Epub 2007 May 22. PMID: 17576053.