PXS-4681A | CAS#1478364-87-2 | SSAO/VAP-1 inhibitor

MedKoo Cat#: 463652 | Name: PXS-4681A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PXS-4681A is a novel potent and selective mechanism-based inhibitor of SSAO/VAP-1 with anti-inflammatory effects in vivo.

Chemical Structure

PXS-4681A

CAS#1478364-87-2

Theoretical Analysis

MedKoo Cat#: 463652

Name: PXS-4681A

CAS#: 1478364-87-2

Chemical Formula: C10H14ClFN2O3S

Exact Mass: 296.0398

Molecular Weight: 296.74

Elemental Analysis: C, 40.48; H, 4.76; Cl, 11.95; F, 6.40; N, 9.44; O, 16.17; S, 10.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PXS-4681A; PXS4681A; PXS 4681A;

IUPAC/Chemical Name

(Z)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)benzenesulfonamide hydrochloride

InChi Key

VBGNJMUEMDYZJJ-HGKIGUAWSA-N

InChi Code

InChI=1S/C10H13FN2O3S.ClH/c11-5-8(6-12)7-16-9-1-3-10(4-2-9)17(13,14)15;/h1-5H,6-7,12H2,(H2,13,14,15);1H/b8-5-;

SMILES Code

O=S(C1=CC=C(OC/C(CN)=C\F)C=C1)(N)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 296.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Thézénas ML, De Leo B, Laux-Biehlmann A, Bafligil C, Elger B, Tapmeier T, Morten K, Rahmioglu N, Dakin SG, Charles P, Martinez FE, Steers G, Fischer OM, Mueller J, Hess-Stumpp H, Steinmeyer A, Manek S, Zondervan KT, Kennedy S, Becker CM, Shang C, Zollner TM, Kessler BM, Oppermann U. Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions. Sci Rep. 2020 Jan 30;10(1):1495. doi: 10.1038/s41598-020-58362-3. Erratum in: Sci Rep. 2020 Mar 24;10(1):5665. PMID: 32001775; PMCID: PMC6992811. 2: Becchi S, Buson A, Foot J, Jarolimek W, Balleine BW. Inhibition of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 reduces lipopolysaccharide-induced neuroinflammation. Br J Pharmacol. 2017 Jul;174(14):2302-2317. doi: 10.1111/bph.13832. Epub 2017 Jun 10. PMID: 28437839; PMCID: PMC5481640. 3: Foot JS, Yow TT, Schilter H, Buson A, Deodhar M, Findlay AD, Guo L, McDonald IA, Turner CI, Zhou W, Jarolimek W. PXS-4681A, a potent and selective mechanism- based inhibitor of SSAO/VAP-1 with anti-inflammatory effects in vivo. J Pharmacol Exp Ther. 2013 Nov;347(2):365-74. doi: 10.1124/jpet.113.207613. Epub 2013 Aug 13. PMID: 23943052.