Synonym
Aptazapine; CGS7525 A; CGS-7525 A; CGS 7525 A
IUPAC/Chemical Name
2-methyl-1,3,4,14b-tetrahydro-2H,10H-benzo[e]pyrazino[2,1-c]pyrrolo[1,2-a][1,4]diazepine
InChi Key
MNHDDERDSNZCCK-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19N3/c1-17-9-10-19-14-6-3-2-5-13(14)11-18-8-4-7-15(18)16(19)12-17/h2-8,16H,9-12H2,1H3
SMILES Code
CN1CCN2C(c3n(Cc4c2cccc4)ccc3)C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
253.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gower AJ, Broekkamp CL, Rijk HW, Van Delft AM. Pharmacological evaluation of in vivo tests for alpha 2-adrenoceptor blockade in the central nervous system and the effects of the enantiomers of mianserin and its aza-analog ORG 3770. Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:185-201. PMID: 2896489.
2: DeHaas Vermeulen J, Thompson TA. Assay for the determination of the tetracyclic antidepressant compound aptazapine in plasma by high-performance liquid chromatography. J Chromatogr. 1984 Mar 9;306:412-6. doi: 10.1016/s0378-4347(00)80908-1. PMID: 6715482.
3: Cirilli R, Orlando V, Ferretti R, Turchetto L, Silvestri R, De Martino G, La Torre F. Direct HPLC enantioseparation of chiral aptazepine derivatives on coated and immobilized polysaccharide-based chiral stationary phases. Chirality. 2006 Aug;18(8):621-32. doi: 10.1002/chir.20298. PMID: 16715514.
4: Liebman JM, Lovell RA, Braunwalder A, Stone G, Bernard P, Barbaz B, Welch J, Kim HS, Wasley JW, Robson RD. CGS 7525A, a new, centrally active alpha 2 adrenoceptor antagonist. Life Sci. 1983 Jan 24;32(4):355-63. doi: 10.1016/0024-3205(83)90081-4. PMID: 6131367.
