MedKoo Cat#: 412730 | Name: AzoLPA
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lysophosphatidic acid (LPA) acts as an extracellular signaling molecule and activates LPA1-6 receptors. These receptors are of particular importance in the nervous, cardiovascular, reproductive, gastrointestinal, and pulmonary systems. AzoLPA is embedded with an azobenzene photoswitch which enables the optical control of LPA receptor activation. The light-induced cis- form shows greater activation of LPA receptors than its dark-adapted trans- form.

Chemical Structure

AzoLPA
AzoLPA
CAS#2389048-52-4

Theoretical Analysis

MedKoo Cat#: 412730

Name: AzoLPA

CAS#: 2389048-52-4

Chemical Formula: C23H34N3O7P

Exact Mass: 495.2134

Molecular Weight: 495.51

Elemental Analysis: C, 55.75; H, 6.92; N, 8.48; O, 22.60; P, 6.25

Price and Availability

Size Price Availability Quantity
5mg USD 850.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
AzoLPA; 1-(E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl]-2-hydroxy-sn-glycero-3-phosphate (ammonium salt)
IUPAC/Chemical Name
ammonium (R,E)-3-((4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl)oxy)-2-hydroxypropyl hydrogen phosphate
InChi Key
ZIDGAEVBOOGIDF-OGEVYCCMSA-N
InChi Code
InChI=1S/C23H31N2O7P.H3N/c1-2-3-5-18-8-12-20(13-9-18)24-25-21-14-10-19(11-15-21)6-4-7-23(27)31-16-22(26)17-32-33(28,29)30;/h8-15,22,26H,2-7,16-17H2,1H3,(H2,28,29,30);1H3/b25-24+;/t22-;/m1./s1
SMILES Code
OP(OC[C@]([H])(O)COC(CCCC1=CC=C(/N=N/C2=CC=C(CCCC)C=C2)C=C1)=O)([O-])=O.[NH4+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 495.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Morstein J, Dacheux MA, Norman DD, Shemet A, Donthamsetti PC, Citir M, Frank JA, Schultz C, Isacoff EY, Parrill AL, Tigyi GJ, Trauner D. Optical Control of Lysophosphatidic Acid Signaling. J Am Chem Soc. 2020 Jun 17;142(24):10612-10616. doi: 10.1021/jacs.0c02154. Epub 2020 Jun 5. PMID: 32469525.