MedKoo Cat#: 564288 | Name: ZWM026

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZWM026 is a multi-target inhibitor, and an indolocarbazoles analogue derived from mangrove in coastal marine wetland. ZWM026 exhibits selectivity and reversibility against T790M mutant over wild-type EGFR in naturally occurring NSCLC cells and constructed NIH-3T3 cells.

Chemical Structure

ZWM026
ZWM026
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564288

Name: ZWM026

CAS#: NONE

Chemical Formula: C23H17N3O3

Exact Mass: 383.1270

Molecular Weight: 383.41

Elemental Analysis: C, 72.05; H, 4.47; N, 10.96; O, 12.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ZWM-026; ZWM 026; ZWM026
IUPAC/Chemical Name
12-Ethyl-6-(hydroxymethyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
InChi Key
ZYYKZAMVYVBWFE-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H17N3O3/c1-2-25-15-10-6-4-8-13(15)17-19-18(22(28)26(11-27)23(19)29)16-12-7-3-5-9-14(12)24-20(16)21(17)25/h3-10,24,27H,2,11H2,1H3
SMILES Code
O=C1N(CO)C(C2=C1C3=C(C4=C2C5=C(N4CC)C=CC=C5)NC6=C3C=CC=C6)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 383.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Song X, Qi X, Wang Q, Zhu W, Li J. A novel multi-target inhibitor harboring selectivity of inhibiting EGFR T790M sparing wild-type EGFR. Am J Cancer Res. 2017 Sep 1;7(9):1884-1898. eCollection 2017. PubMed PMID: 28979811; PubMed Central PMCID: PMC5622223.