MedKoo Cat#: 463624 | Name: NBI-98782
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NBI-98782 is a potent vesicular monoamine transporter (VMAT2) inhibitor.

Chemical Structure

NBI-98782
NBI-98782
CAS#85081-18-1

Theoretical Analysis

MedKoo Cat#: 463624

Name: NBI-98782

CAS#: 85081-18-1

Chemical Formula: C19H29NO3

Exact Mass: 319.2147

Molecular Weight: 319.45

Elemental Analysis: C, 71.44; H, 9.15; N, 4.38; O, 15.03

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
NBI-98782; NBI98782; NBI 98782; (+)-DTBZ; (+)-α-Dihydrotetrabenazine; (+)-α-DHTBZ;
IUPAC/Chemical Name
(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
InChi Key
WEQLWGNDNRARGE-DJIMGWMZSA-N
InChi Code
InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3/t14-,16-,17-/m1/s1
SMILES Code
COC1=C(OC)C=C2C(CCN3[C@@H]2C[C@@H](O)[C@H](CC(C)C)C3)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 319.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Huang M, He W, Rajagopal L, Kudwa A, Grigoriadis DE, Meltzer HY. Effects of NBI-98782, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, on neurotransmitter efflux and phencyclidine-induced locomotor activity: Relevance to tardive dyskinesia and antipsychotic action. Pharmacol Biochem Behav. 2020 Mar;190:172872. doi: 10.1016/j.pbb.2020.172872. Epub 2020 Feb 18. PMID: 32084491. 2: Luo R, Bozigian H, Jimenez R, Loewen G, O'Brien CF. Single Dose and Repeat Once-Daily Dose Safety, Tolerability and Pharmacokinetics of Valbenazine in Healthy Male Subjects. Psychopharmacol Bull. 2017 Aug 1;47(3):44-52. PMID: 28839339; PMCID: PMC5546550.