MedKoo Cat#: 575333 | Name: Iododoxorubicin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Iododoxorubicin is a lipophilic derivative of doxorubicin which differs from the parent compound in substitution of hydroxyl group on the daunosamine sugar moiety.

Chemical Structure

Iododoxorubicin
Iododoxorubicin
CAS#83997-75-5

Theoretical Analysis

MedKoo Cat#: 575333

Name: Iododoxorubicin

CAS#: 83997-75-5

Chemical Formula: C27H28INO10

Exact Mass: 653.0758

Molecular Weight: 653.42

Elemental Analysis: C, 49.63; H, 4.32; I, 19.42; N, 2.14; O, 24.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
FCE 21954; FCE21954; FCE-21954; WP 154; WP-154; WP154; Iododoxorubicin; 4'-Deoxy-4'-iodoadriamycin; 4'-Deoxy-4'-iododoxorubicin; 4'-Iodo-4'-deoxydoxorubicin;
IUPAC/Chemical Name
5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((4-aminotetrahydro-5-iodo-6-methyl-2H-pyran-2-yl)oxy)-8-(hydroxyacetyl)-1-methoxy-6,8,11-trihydroxy-, (2R-(2-alpha(8S*,10S*),4-beta,5-beta,6-beta))-
InChi Key
PDQGEKGUTOTUNV-TZSSRYMLSA-N
InChi Code
InChI=1S/C27H28INO10/c1-10-22(28)13(29)6-17(38-10)39-15-8-27(36,16(31)9-30)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,30,33,35-36H,6-9,29H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
SMILES Code
COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](I)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 653.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Twelves CJ, Dobbs NA, Lawrence MA, Ramirez AJ, Summerhayes M, Richards MA, Towlson KE, Rubens RD. Iododoxorubicin in advanced breast cancer: a phase II evaluation of clinical activity, pharmacology and quality of life. Br J Cancer. 1994 Apr;69(4):726-31. doi: 10.1038/bjc.1994.137. PMID: 8142261; PMCID: PMC1968796. 2. Edwards DM, Marrari P, Efthymiopoulos C, Basileo G, Fraier D, Pianezzola E, Strolin-Benedetti M. Pharmacokinetics of iododoxorubicin in the rat, dog, and monkey. Drug Metab Dispos. 1991 Sep-Oct;19(5):938-45. PMID: 1686240.