AVN-322 | CAS#1194574-68-9 | CAS#1194574-33-8 | 5-HT6 Antagonist

MedKoo Cat#: 527726 | Name: AVN-322

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AVN-322 is a 5-hydroxytryptamine subtype 6 receptor (5-HT6) antagonist potentially for the treatment of Alzheimer's disease. 5-HT6R antagonists are shown to improve cognition in animal models of cognitive impairment. AVN-322 significantly restored both scopolamine- and MK-801-induced cognitive dysfunction.

Chemical Structure

AVN-322

CAS#1194574-68-9

Theoretical Analysis

MedKoo Cat#: 527726

Name: AVN-322

CAS#: 1194574-68-9

Chemical Formula: C17H20ClN5O2S

Exact Mass:

Molecular Weight: 393.89

Elemental Analysis: C, 51.84; H, 5.12; Cl, 9.00; N, 17.78; O, 8.12; S, 8.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1194574-68-9; 1194574-33-8

Synonym

AVN-322; AVN 322; AVN322

IUPAC/Chemical Name

N,7-dimethyl-3-(phenylsulfonyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-2-amine hydrochloride

InChi Key

HLQZXWFRTGIZIJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H19N5O2S.ClH/c1-18-16-15(25(23,24)13-6-4-3-5-7-13)17-19-10-12-11-21(2)9-8-14(12)22(17)20-16;/h3-7,10H,8-9,11H2,1-2H3,(H,18,20);1H

SMILES Code

O=S(C1=C2N=CC(CN(C)CC3)=C3N2N=C1NC)(C4=CC=CC=C4)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 393.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ivachtchenko AV, Ivanenkov YA, Veselov MS, Ikun IM. AVN-322 is a Safe Orally Bio-Available Potent and Highly Selective Antagonist of 5-HT6R with Demonstrated Ability to Improve Impaired Memory in Animal Models. Curr Alzheimer Res. 2016 Nov 7. [Epub ahead of print] PubMed PMID: 27829340.