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MedKoo Cat#: 575312 | Name: SHR-116837

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SHR-116837 is a metabolite of Famitinib.

Chemical Structure

SHR-116837
SHR-116837
CAS#1044039-04-4

Theoretical Analysis

MedKoo Cat#: 575312

Name: SHR-116837

CAS#: 1044039-04-4

Chemical Formula: C21H23FN4O2

Exact Mass: 382.1805

Molecular Weight: 382.44

Elemental Analysis: C, 65.95; H, 6.06; F, 4.97; N, 14.65; O, 8.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Famitinib metabolite M3; SHR-116837; SHR116837; SHR 116837
IUPAC/Chemical Name
4H-Pyrrolo(3,2-C)pyridin-4-one, 5-(2-(ethylamino)ethyl)-2-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-1,5,6,7-tetrahydro-3-methyl
InChi Key
YTUMZRDKADJBSW-PTNGSMBKSA-N
InChi Code
InChI=1S/C21H23FN4O2/c1-3-23-7-9-26-8-6-17-19(21(26)28)12(2)18(24-17)11-15-14-10-13(22)4-5-16(14)25-20(15)27/h4-5,10-11,23-24H,3,6-9H2,1-2H3,(H,25,27)/b15-11-
SMILES Code
CCNCCN1CCc2[nH]c(\C=C\3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 382.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Chen Q, Tang L, Liu N, Han F, Guo L, Guo S, Wang J, Liu H, Ye Y, Zhang L, Liu L, Wang P, Li Y, He Q, Yang X, Tang Q, Li Y, Liang Y, Sun X, Xie C, Mo Y, Guo Y, Sun R, Mo H, Cao K, Guo X, Zeng M, Mai H, Ma J. Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study. Cancer Commun (Lond). 2018 Nov 1;38(1):66. doi: 10.1186/s40880-018-0330-z. PMID: 30382933; PMCID: PMC6235389. 2. Xu RH, Shen L, Wang KM, Wu G, Shi CM, Ding KF, Lin LZ, Wang JW, Xiong JP, Wu CP, Li J, Liu YP, Wang D, Ba Y, Feng JP, Bai YX, Bi JW, Ma LW, Lei J, Yang Q, Yu H. Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial. Chin J Cancer. 2017 Dec 22;36(1):97. doi: 10.1186/s40880-017-0263-y. PMID: 29273089; PMCID: PMC5741870. 3. Ge S, Zhang Q, He Q, Zou J, Liu X, Li N, Tian T, Zhu Y, Gao J, Shen L. Famitinib exerted powerful antitumor activity in human gastric cancer cells and xenografts. Oncol Lett. 2016 Sep;12(3):1763-1768. doi: 10.3892/ol.2016.4909. Epub 2016 Jul 25. PMID: 27602110; PMCID: PMC4998225.

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