IUPAC/Chemical Name
(E)-2,3-dibromo-4,4-bis(4-ethylphenyl)but-2-enoic acid
InChi Key
VJHYTULURZUAAF-VHEBQXMUSA-N
InChi Code
InChI=1S/C20H20Br2O2/c1-3-13-5-9-15(10-6-13)17(18(21)19(22)20(23)24)16-11-7-14(4-2)8-12-16/h5-12,17H,3-4H2,1-2H3,(H,23,24)/b19-18+
SMILES Code
CCc1ccc(C(c2ccc(CC)cc2)/C(Br)=C(C(O)=O)\Br)cc1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
452.19
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Drsata J, Hais IM, Malon P. Interaction of Z-4,4-bis(4-ethylphenyl)-2,3-dibromo-2-butenoic acid with aminotransferases: changes in absorption and circular dichroism spectra. Drug Metabol Drug Interact. 1991;9(3-4):255-68. doi: 10.1515/dmdi.1991.9.3-4.255. PMID: 1824079.
2: Klimes J, Zahradnícek M. HPLC-Bestimmung des Cancerostaticums Edikron im Ratten-plasma [HPLC determination of the carcinostatic Edikron in rat plasma]. Pharmazie. 1987 Oct;42(10):699. German. PMID: 3438326.
3: Klíma J, Grafnetterová J, Jiricka Z, Masek K. Study of the effect of Edikron on the immune system. Physiol Bohemoslov. 1985;34(2):183-7. PMID: 3161109.
4: Francová V, Smolík S, Schlehrová M, Krepelka J, Ausková M, Franc Z, Rezábek K, Semonský M. Biochemistry of drugs. XXIV. Substances with antineoplastic effect. LXII. Pharmacokinetics of gamma,gamma-bis-4-ethylphenyl-alpha,beta- dibromoisocrotonic acid-3H (Edikron-3H) in experimental animals. Neoplasma. 1978;25(4):395-404. PMID: 692801.
5: Sýkora I, Gandalovicová D. Dominant-lethal assay of selected cytostatics. Neoplasma. 1978;25(5):523-33. PMID: 581697.
6: Helia O, Jindra A, Semonský M, Slavíková M. Vliv kyseliny gamma, gamma-bis-p- ethylfenyl-alpha,beta-di-bromisokrotonové (Edikronu) na nĕkteré enzymy in vitro [Effect of gamma, gamma-bis-p-ethylpenyl-alpha,beta-di-bromisocrotonic acid (Edikron) on various enzymes in vitro]. Cesk Farm. 1973 Nov;22(9):404-5. Czech. PMID: 4775961.
