Synonym
Cetirizine (free base); AC170; AC 170 AC-170
IUPAC/Chemical Name
Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
InChi Key
ZKLPARSLTMPFCP-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)
SMILES Code
O=C(O)COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
388.89
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ekstrand C, Ingvast-Larsson C, Bondesson U, Hedeland M, Olsén L. Cetirizine per os: exposure and antihistamine effect in the dog. Acta Vet Scand. 2018 Nov 26;60(1):77. doi: 10.1186/s13028-018-0431-3. PMID: 30477556; PMCID: PMC6258303.
2: Nayak AS, Berger WE, LaForce CF, Urdaneta ER, Patel MK, Franklin KB, Wu MM. Randomized, placebo-controlled study of cetirizine and loratadine in children with seasonal allergic rhinitis. Allergy Asthma Proc. 2017 May 1;38(3):222-230. doi: 10.2500/aap.2017.38.4050. PMID: 28441993.
3: Rossi A, Campo D, Fortuna MC, Garelli V, Pranteda G, De Vita G, Sorriso-Valvo L, Di Nunno D, Carlesimo M. A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia. J Dermatolog Treat. 2018 Mar;29(2):149-151. doi: 10.1080/09546634.2017.1341610. Epub 2017 Jun 29. PMID: 28604133.
4: Groschner K, Pöch G. Cetirizin [Cetirizine]. Dtsch Med Wochenschr. 1998 Dec 11;123(50):1523-4. German. doi: 10.1055/s-0029-1237295. PMID: 9879282.
5: Chen C. Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine. Curr Med Chem. 2008;15(21):2173-91. doi: 10.2174/092986708785747625. PMID: 18781943.
6: Knych HK, Weiner D, Steinmetz S, Flynn K, McKemie DS. Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2019 Nov;42(6):617-623. doi: 10.1111/jvp.12808. Epub 2019 Sep 6. PMID: 31490561.
7: Sedivý J. Cetirizin [Cetirizine]. Cesk Pediatr. 1993 Dec;48(12):729. Czech. PMID: 8137448.
8: Zhang L, Cheng L, Hong J. The clinical use of cetirizine in the treatment of allergic rhinitis. Pharmacology. 2013;92(1-2):14-25. doi: 10.1159/000351843. Epub 2013 Jul 18. PMID: 23867423.
9: Rutkowski K, Wagner A. Cetirizine anaphylaxis. Ann Allergy Asthma Immunol. 2014 Sep;113(3):247-9. doi: 10.1016/j.anai.2014.06.030. PMID: 25168222.
10: Abdelmaksoud A. Topical cetirizine 1% for treatment of androgenetic alopecia. Dermatol Ther. 2017 Nov;30(6). doi: 10.1111/dth.12530. Epub 2017 Aug 10. PMID: 28796428.
