Synonym
Cetaben sodium; CL203821; CL-203821; CL 203821
IUPAC/Chemical Name
Benzoic acid, 4-(hexadecylamino)-, sodium salt
InChi Key
RIEGDRWQKNITRV-UHFFFAOYSA-M
InChi Code
InChI=1S/C23H39NO2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-24-22-18-16-21(17-19-22)23(25)26;/h16-19,24H,2-15,20H2,1H3,(H,25,26);/q;+1/p-1
SMILES Code
O=C([O-])C1=CC=C(NCCCCCCCCCCCCCCCC)C=C1.[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
383.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Albright JD, Schaffer SA, Shepherd RG. Cetaben sodium, an antiatherosclerotic agent. J Pharm Sci. 1979 Jul;68(7):936-7. doi: 10.1002/jps.2600680749. PMID: 313437.
2: Katocs AS Jr, Schaffer SA. Antiatherogenic activity of cetaben sodium, sodium p-(hexadecylamino) benzoate, in the aortae of hypercholesteremic rabbits subjected to aortic endothelial cell desquamation. Artery. 1982;11(3):192-206. PMID: 6985202.
3: Chow SL, Sims BE. Micellar solubilization of cetaben sodium in surfactant and lipid solutions. J Pharm Sci. 1981 Aug;70(8):924-6. doi: 10.1002/jps.2600700823. PMID: 6975813.
4: Kunitomo M, Takaoka K, Matsumoto J, Iwai H, Bando Y. [Experimental induction of atherosclerosis in guinea pigs fed a cholesterol and vitamin D2-rich diet]. Nihon Yakurigaku Zasshi. 1983 Apr;81(4):275-83. Japanese. PMID: 6604004.
5: Albright JD, DeVries VG, Largis EE, Miner TG, Reich MF, Schaffer SA, Shepherd RG, Upeslacis J. Potential antiatherosclerotic agents. 2. (Aralkylamino)- and (alkylamino) benzoic acid analogues of cetaben. J Med Chem. 1983 Oct;26(10):1378-93. doi: 10.1021/jm00364a009. PMID: 6604816.
6: Oker-Blom C. Toxicological studies on 4-(hexadecylamino)benzoate (PHB), an agent with anti-atherosclerotic properties, in the rat. Toxicol Lett. 1981 Jan;7(3):273-7. doi: 10.1016/0378-4274(81)90081-3. PMID: 6971504.
