Synonym
AZD-7325 hydrogen sulfate; AZD7325 hydrogen sulfate; AZD 7325 hydrogen sulfate
IUPAC/Chemical Name
3-Cinnolinecarboxamide, 4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propyl-, sulfate (1:1)
InChi Key
BPPOEEBZBHFARK-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H19FN4O2.H2O4S/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2;1-5(2,3)4/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25);(H2,1,2,3,4)
SMILES Code
CCCNC(=O)c1nnc2c(cccc2c1N)c3c(F)cccc3OC.OS(=O)(=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
452.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Te Beek ET, Chen X, Jacobs GE, Nahon KJ, de Kam ML, Lappalainen J, Cross AJ, van Gerven JM, Hay JL. The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels. Clin Pharmacol Drug Dev. 2015 Mar;4(2):149-54. doi: 10.1002/cpdd.134. Epub 2014 Aug 28. PubMed PMID: 27128218.
2: Chen X, Jacobs G, de Kam M, Jaeger J, Lappalainen J, Maruff P, Smith MA, Cross AJ, Cohen A, van Gerven J. The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males. Br J Clin Pharmacol. 2014 Dec;78(6):1298-314. doi: 10.1111/bcp.12413. PubMed PMID: 24802722; PubMed Central PMCID: PMC4256620.
3: Zhou D, Lu Z, Sunzel M, Xu H, Al-Huniti N. Population pharmacokinetic modelling to assess clinical drug-drug interaction between AZD7325 and midazolam. J Clin Pharm Ther. 2014 Aug;39(4):404-10. doi: 10.1111/jcpt.12152. Epub 2014 Apr 1. PubMed PMID: 24689515.
4: Zhou D, Sunzel M, Ribadeneira MD, Smith MA, Desai D, Lin J, Grimm SW. A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison. Br J Clin Pharmacol. 2012 Jul;74(1):98-108. doi: 10.1111/j.1365-2125.2011.04155.x. PubMed PMID: 22122233; PubMed Central PMCID: PMC3394133.
