Synonym
Azamplus; Elicodil; Helirad; Pylorisan; Ranitidine bismuth citrate; Tritec
IUPAC/Chemical Name
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, bismuth(3(+)) salt (1:1), compd. with N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine (1:1)
InChi Key
XAUTYMZTJWXZHZ-UHFFFAOYSA-K
InChi Code
InChI=1S/C13H22N4O3S.C6H8O7.Bi/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10;/h4-5,9,14-15H,6-8,10H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;;+3/p-3
SMILES Code
[Bi+3].CNC(=C[N+](=O)[O-])NCCSCc1oc(CN(C)C)cc1.OC(CC(=O)[O-])(CC(=O)[O-])C(=O)[O-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
712.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Selbes M, Beita-Sandí W, Kim D, Karanfil T. The role of chloramine species in NDMA formation. Water Res. 2018 Apr 16;140:100-109. doi: 10.1016/j.watres.2018.04.033. [Epub ahead of print] PubMed PMID: 29702375.
2: de Araújo ERD, Guerra GCB, Araújo DFS, de Araújo AA, Fernandes JM, de Araújo Júnior RF, da Silva VC, de Carvalho TG, Ferreira LS, Zucolotto SM. Gastroprotective and Antioxidant Activity of Kalanchoe brasiliensis and Kalanchoe pinnata Leaf Juices against Indomethacin and Ethanol-Induced Gastric Lesions in Rats. Int J Mol Sci. 2018 Apr 24;19(5). pii: E1265. doi: 10.3390/ijms19051265. PubMed PMID: 29695040.
3: Allen SJ, Chazot PL, Dixon CJ. Can H(2) -receptor upregulation and raised histamine explain an anaphylactoid reaction on cessation of ranitidine in a 19-year-old female? A case report. Br J Clin Pharmacol. 2018 Apr 18. doi: 10.1111/bcp.13578. [Epub ahead of print] PubMed PMID: 29667234.
4: Kennedy L, Hargrove L, Demieville J, Karstens A, Jones H, DeMorrow S, Meng F, Invernizzi P, Bernuzzi F, Alpini G, Smith S, Akers A, Meadows V, Francis H. Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2(-/-) mice and human cholangiocarcinoma tumorigenesis. Hepatology. 2018 Mar 30. doi: 10.1002/hep.29898. [Epub ahead of print] PubMed PMID: 29601088.
