HM90822 | CAS#1363145-46-3 | IAPs antagonist

MedKoo Cat#: 463489 | Name: HM90822

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HM90822 is a novel antagonist to the inhibitors of apoptosis (IAPs), potentiating cell death in EGFR-overexpressing non-small-cell lung cancer cells.

Chemical Structure

HM90822

CAS#1363145-46-3 (free base)

Theoretical Analysis

MedKoo Cat#: 463489

Name: HM90822

CAS#: 1363145-46-3 (free base)

Chemical Formula: C30H36ClF2N7O4

Exact Mass: 631.2485

Molecular Weight: 632.11

Elemental Analysis: C, 57.00; H, 5.74; Cl, 5.61; F, 6.01; N, 15.51; O, 10.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1363145-46-3 (free base) 1363150-35-9 (HCl)

Synonym

HM90822; HM-90822; HM 90822; HM822; HM 822; HM-822; HM90822B; HM-90822B; HM 90822B;

IUPAC/Chemical Name

(S)-N-(4-((3-chloro-2,4-difluorophenyl)amino)-7-methoxyquinazolin-6-yl)-1-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide

InChi Key

KJLMHHDQQFRBTF-HHCYOLOASA-N

InChi Code

InChI=1S/C30H36ClF2N7O4/c1-15(34-5)27(41)39-25(30(2,3)4)29(43)40-11-7-8-21(40)28(42)38-20-12-16-19(13-22(20)44-6)35-14-36-26(16)37-18-10-9-17(32)23(31)24(18)33/h9-10,12-15,21,25,34H,7-8,11H2,1-6H3,(H,38,42)(H,39,41)(H,35,36,37)/t15-,21-,25+/m0/s1

SMILES Code

O=C([C@H]1N(C([C@@H](NC([C@@H](NC)C)=O)C(C)(C)C)=O)CCC1)NC2=CC3=C(NC4=CC=C(F)C(Cl)=C4F)N=CN=C3C=C2OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 632.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hong SW, Shin JS, Moon JH, Jung SA, Koh DI, Ryu Y, Park YS, Kim DY, Park SS, Hong JK, Kim EH, Kim MJ, Jeong HR, Bae IH, Ahn YG, Suh KH, Cho IJ, Kang JS, Hong YS, Lee JS, Jin DH, Kim TW. Chemosensitivity to HM90822, a novel synthetic IAP antagonist, is determined by p-AKT-inducible XIAP phosphorylation in human pancreatic cancer cells. Invest New Drugs. 2020 Dec;38(6):1696-1706. doi: 10.1007/s10637-020-00956-9. Epub 2020 May 27. PMID: 32462369.