ID09 is a Potent Tubulin Polymerization Inhibitor. ID09 showed excellent aqueous solubility and favorable Log P value and displayed noteworthily low nanomolar potency against a variety of tumor cells, including those taxol-resistant ones. ID09 inhibited tubulin polymerization, disrupted cellular microtubule networks by targeting the colchicine site, and promoted HepG2 cell cycle arrest and cell apoptosis. In the HepG2 xenograft mouse model.
MedKoo Cat#: 463463
Name: ID09
CAS#: unknown
Chemical Formula: C24H32Cl2N4O3
Exact Mass: 494.1851
Molecular Weight: 495.45
Elemental Analysis: C, 58.18; H, 6.51; Cl, 14.31; N, 11.31; O, 9.69
The following data is based on the product molecular weight 495.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
