MedKoo Cat#: 555884 | Name: BI-187004
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BI-187004, also known as VTP-34072, is an 11β-hydroxysteroid dehydrogenase 1 inhibitor. BI187004/VTP-34072 is being studied for the treatment of type 2 diabetes and metabolic syndrome. In preclinical studies, BI187004/VTP-34072 had a positive impact on multiple cardiovascular and metabolic risk factors associated with metabolic syndrome, which differentiates it from other classes of type 2 diabetes drugs.

Chemical Structure

BI-187004
BI-187004
CAS#1303515-32-3

Theoretical Analysis

MedKoo Cat#: 555884

Name: BI-187004

CAS#: 1303515-32-3

Chemical Formula: C21H18N4O

Exact Mass: 342.1481

Molecular Weight: 342.40

Elemental Analysis: C, 73.67; H, 5.30; N, 16.36; O, 4.67

Price and Availability

Size Price Availability Quantity
1mg USD 75.00 Ready to ship
5mg USD 250.00 Ready to ship
10mg USD 450.00 Ready to ship
25mg USD 950.00 Ready to ship
50mg USD 1,450.00 Ready to ship
100mg USD 2,450.00 Ready to ship
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Related CAS #
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Synonym
BI-187004; BI 187004; BI187004; VTP-34072; VTP 34072; VTP34072;
IUPAC/Chemical Name
(4aR,9aS)-1-(1H-Benzimidazol-6-ylcarbonyl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-6-carbonitrile
InChi Key
VVZNCSHIBODHMZ-UZLBHIALSA-N
InChi Code
InChI=1S/C21H18N4O/c22-11-13-3-4-14-10-20-16(17(14)8-13)2-1-7-25(20)21(26)15-5-6-18-19(9-15)24-12-23-18/h3-6,8-9,12,16,20H,1-2,7,10H2,(H,23,24)/t16-,20+/m1/s1
SMILES Code
O=C(N(CCC1)[C@]2(CC3=C(C=C(C=C3)C#N)[C@@]12[H])[H])C4=CC=C5N=CNC5=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 342.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Maw HH, Zeng X, Campbell S, Taub ME, Teitelbaum AM. N-Methylation of BI 187004 by Thiol S-Methyltransferase. Drug Metab Dispos. 2018 Jun;46(6):770-778. doi: 10.1124/dmd.117.079764. Epub 2018 Mar 7. PMID: 29514826.