Synonym
(–)-Mycousnine; Mycousunin;
IUPAC/Chemical Name
1,1'-((4aR,9bS)-3,7,9-trihydroxy-4a-methoxy-8,9b-dimethyl-1-oxo-1,4,4a,9b-tetrahydrodibenzo[b,d]furan-2,6-diyl)bis(ethan-1-one)
InChi Key
WWSUFZCWOJULTK-RBUKOAKNSA-N
InChi Code
InChI=1S/C19H20O8/c1-7-14(23)12(9(3)21)16-13(15(7)24)18(4)17(25)11(8(2)20)10(22)6-19(18,26-5)27-16/h22-24H,6H2,1-5H3/t18-,19+/m0/s1
SMILES Code
CO[C@@]12[C@@](C(C(C(C)=O)=C(O)C2)=O)(C)C3=C(C(C)=C(C(C(C)=O)=C3O1)O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
376.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lee J, Lee J, Kim GJ, Yang I, Wang W, Nam JW, Choi H, Nam SJ, Kang H. Mycousfurans A and B, Antibacterial Usnic Acid Congeners from the Fungus Mycosphaerella sp., Isolated from a Marine Sediment. Mar Drugs. 2019 Jul 19;17(7):422. doi: 10.3390/md17070422. PMID: 31331101; PMCID: PMC6669435.
2: Wang LW, Wang JL, Chen J, Chen JJ, Shen JW, Feng XX, Kubicek CP, Lin FC, Zhang CL, Chen FY. A Novel Derivative of (-)mycousnine Produced by the Endophytic Fungus Mycosphaerella nawae, Exhibits High and Selective Immunosuppressive Activity on T Cells. Front Microbiol. 2017 Jul 5;8:1251. doi: 10.3389/fmicb.2017.01251. PMID: 28725220; PMCID: PMC5496962.
-Mycousnine4734.jpg "(–)-Mycousnine")
