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MedKoo Cat#: 412536 | Name: Cephradine sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cephradine sodium is the salt form of Cephradine (free base), a semi-synthetic cephalosporin antibiotic. Cefradin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cefradin may interfere with autolysin inhibitors.

Chemical Structure

Cephradine sodium
CAS#57584-26-6 (sodium)

Theoretical Analysis

MedKoo Cat#: 412536

Name: Cephradine sodium

CAS#: 57584-26-6 (sodium)

Chemical Formula: C16H18N3NaO4S

Exact Mass: 0.0000

Molecular Weight: 371.39

Elemental Analysis: C, 51.75; H, 4.89; N, 11.31; Na, 6.19; O, 17.23; S, 8.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
31828-50-9 (dihydrate) 38821-53-3 (free base) 57584-26-6 (sodium)
Synonym
Cephradine sodium; Cefradine sodium; UNII-04FRJ20XNF; Maxisporin
IUPAC/Chemical Name
sodium (6R,7R)-7-((R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
LSEIVBOQBUBVGP-CYJZLJNKSA-M
InChi Code
InChI=1S/C16H19N3O4S.Na/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23);/q;+1/p-1/t10-,11-,15-;/m1./s1
SMILES Code
CC1=C(C([O-])=O)N2[C@@H]([C@@H](C2=O)NC([C@@H](C3=CCC=CC3)N)=O)SC1.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 371.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang YC, Monkhouse DC. Solution stability of cephradine neutralized with arginine or sodium bicarbonate. Am J Hosp Pharm. 1983 Mar;40(3):432-4. PMID: 6303120. 2: Arayne MS, Sultana N, Afzal M. Cephradine antacids interaction studies. Pak J Pharm Sci. 2007 Jul;20(3):179-84. PMID: 17545100. 3: Idoate I, Mendizábal MV, Urdaneta E, Larralde J. Interactions of cephradine and cefaclor with the intestinal absorption of D-galactose. J Pharm Pharmacol. 1996 Jun;48(6):645-50. doi: 10.1111/j.2042-7158.1996.tb05989.x. PMID: 8832502. 4: Dudkowska J, Frańska M, Frański R. Detection of the iron complexes with hydrolysis products of cephalexin and cefradine upon high-performance liquid chromatography/electrospray ionization mass spectrometry analysis. Rapid Commun Mass Spectrom. 2018 Apr 15;32(7):576-582. doi: 10.1002/rcm.8073. PMID: 29397004. 5: Du J, Li H. Sensitive chemiluminescence determination of thirteen cephalosporin antibiotics with luminol-copper(II) reaction. Appl Spectrosc. 2010 Oct;64(10):1154-9. doi: 10.1366/000370210792973613. PMID: 20925986. 6: Omar MA, Abdelmageed OH, Attia TZ. Kinetic spectrophotometric determination of certain cephalosporins in pharmaceutical formulations. Int J Anal Chem. 2009;2009:596379. doi: 10.1155/2009/596379. Epub 2009 Jun 21. PMID: 20140078; PMCID: PMC2814136. 7: Heald AF, Ita CE, Schreiber EC. Fluorometric determination of cephradine in plasma. J Pharm Sci. 1976 May;65(5):768-9. doi: 10.1002/jps.2600650542. PMID: 932955. 8: Niu L, Song Z, He X. A study of the chemiluminescence behavior of cephalosporins with luminol and its analytical application. Drug Metab Lett. 2009 Aug;3(3):144-51. doi: 10.2174/187231209789352157. Epub 2009 Aug 1. PMID: 19702549. 9: Elbalkiny HT, Yehia AM, Riad SM, Elsaharty YS. Derivative constant wavelength synchronous fluorescence spectrometry for the simultaneous detection of cefadrine and cefadroxil in water samples. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Mar 15;229:117903. doi: 10.1016/j.saa.2019.117903. Epub 2019 Dec 17. PMID: 31887677. 10: Li Y, Lu J. Chemiluminescence flow-injection analysis of beta-lactam antibiotics using the luminol-permanganate reaction. Luminescence. 2006 Jul- Aug;21(4):251-5. doi: 10.1002/bio.915. PMID: 16791833.