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MedKoo Cat#: 412533 | Name: Cefquinome

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefquinome is a fourth-generation cephalosporin with pharmacological and antibacterial properties valuable in the treatment of coliform mastitis and other infections. It is only used in veterinary applications.

Chemical Structure

Cefquinome
CAS#84957-30-2 (free base)

Theoretical Analysis

MedKoo Cat#: 412533

Name: Cefquinome

CAS#: 84957-30-2 (free base)

Chemical Formula: C23H24N6O5S2

Exact Mass: 528.1250

Molecular Weight: 528.60

Elemental Analysis: C, 52.26; H, 4.58; N, 15.90; O, 15.13; S, 12.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
84957-30-2 (free base) 118443-89-3 (sulfate)
Synonym
Cefquinome free base; Cefquinoma; Cefquinomum
IUPAC/Chemical Name
(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-3-((5,6,7,8-tetrahydroquinolin-1-ium-1-yl)methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
YWKJNRNSJKEFMK-PQFQYKRASA-N
InChi Code
InChI=1S/C23H24N6O5S2/c1-34-27-16(14-11-36-23(24)25-14)19(30)26-17-20(31)29-18(22(32)33)13(10-35-21(17)29)9-28-8-4-6-12-5-2-3-7-15(12)28/h4,6,8,11,17,21H,2-3,5,7,9-10H2,1H3,(H3-,24,25,26,30,32,33)/b27-16-/t17-,21-/m1/s1
SMILES Code
O=C(C(N12)=C(C[N+]3=C4CCCCC4=CC=C3)CS[C@]2([H])[C@H](NC(/C(C5=CSC(N)=N5)=N\OC)=O)C1=O)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 528.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang L, Wu X, Huang Z, Zhang N, Wu Y, Cai Q, Shen X, Ding H. Pharmacokinetic/pharmacodynamic assessment of cefquinome against Actinobacillus Pleuropneumoniae in a piglet tissue cage infection model. Vet Microbiol. 2018 Jun;219:100-106. doi: 10.1016/j.vetmic.2018.02.027. Epub 2018 Mar 6. PMID: 29778180. 2: Qu S, Dai C, Zhu J, Zhao L, Li Y, Hao Z. Cefquinome-loaded microsphere formulations against Klebsiella pneumonia infection during experimental infections. Drug Deliv. 2018 Nov;25(1):909-915. doi: 10.1080/10717544.2018.1461958. PMID: 29649952; PMCID: PMC6058672. 3: Zhang L, Wu X, Huang Z, Kang Z, Chen Y, Shen X, Cai Q, Ding H. Pharmacokinetic/pharmacodynamic integration of cefquinome against Pasteurella Multocida in a piglet tissue cage model. J Vet Pharmacol Ther. 2019 Jan;42(1):60-66. doi: 10.1111/jvp.12705. Epub 2018 Nov 8. PMID: 30407642. 4: Helmschrodt C, Schmidt K, Bertulat S, Klein L, Finnah A, Heuwieser W, Richter A. Quantitative analysis of cefquinome considering different matrix compositions of bovine colostrum and raw milk. Anal Bioanal Chem. 2018 Nov;410(28):7465-7475. doi: 10.1007/s00216-018-1360-8. Epub 2018 Sep 14. PMID: 30218123. 5: Bachmann J, Helmschrodt C, Richter A, Heuwieser W, Bertulat S. Residue concentration of cefquinome after intramammary dry cow therapy and short dry periods. J Dairy Sci. 2018 Aug;101(8):7540-7550. doi: 10.3168/jds.2017-13826. Epub 2018 May 30. PMID: 29859692. 6: Venkatachalam D, Dumka VK, Ranjan B. Pharmacokinetics of a single intramuscular injection of cefquinome in buffalo calves. J Vet Pharmacol Ther. 2018 Feb;41(1):155-158. doi: 10.1111/jvp.12451. Epub 2017 Sep 11. PMID: 28891215. 7: Zhou YH, Xu CG, Yang YB, Xing XX, Liu X, Qu QW, Ding WY, Bello-Onaghise G, Li YH. Histidine Metabolism and IGPD Play a Key Role in Cefquinome Inhibiting Biofilm Formation of Staphylococcus xylosus. Front Microbiol. 2018 Apr 5;9:665. doi: 10.3389/fmicb.2018.00665. PMID: 29675012; PMCID: PMC5896262. 8: Zhang L, Yao L, Kang Z, Huang Z, Gu X, Shen X, Ding H. Microdialysis Determination of Cefquinome Pharmacokinetics in Murine Thigh From Healthy, Neutropenic, and Actinobacillus pleuropneumoniae-Infected Mice. Front Pharmacol. 2019 Mar 12;10:249. doi: 10.3389/fphar.2019.00249. PMID: 30914957; PMCID: PMC6422941. 9: Elazab ST, Schrunk DE, Griffith RW, Ensley SM, Dell'Anna G, Mullin K, Elsayed MG, Amer MS, El-Nabtity SM, Hsu WH. Pharmacokinetics of cefquinome in healthy and Pasteurella multocida-infected rabbits. J Vet Pharmacol Ther. 2018 Jun;41(3):374-377. doi: 10.1111/jvp.12489. Epub 2018 Jan 31. PMID: 29383736. 10: Qu S, Zhao L, Zhu J, Wang C, Dai C, Guo H, Hao Z. Preparation and testing of cefquinome-loaded poly lactic-co-glycolic acid microspheres for lung targeting. Drug Deliv. 2017 Nov;24(1):745-751. doi: 10.1080/10717544.2017.1321058. PMID: 28454494.