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MedKoo Cat#: 412512 | Name: Cefepime sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefepime sulfate is an antibiotic that has been shown to be effective against febrile neutropenia.

Chemical Structure

Cefepime sulfate
CAS#107648-78-2 (sulfate)

Theoretical Analysis

MedKoo Cat#: 412512

Name: Cefepime sulfate

CAS#: 107648-78-2 (sulfate)

Chemical Formula: C19H26N6O9S3

Exact Mass: 0.0000

Molecular Weight: 578.63

Elemental Analysis: C, 39.44; H, 4.53; N, 14.52; O, 24.88; S, 16.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
103296-32-8 (compound E) 123171-59-5 (2HCl hydrate) 88040-23-7 (free base) 107648-78-2 (sulfate) 107648-80-6 (2HCl)
Synonym
Cefepime sulfate; UNII-YP33Y0FYAE
IUPAC/Chemical Name
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;sulfuric acid
InChi Key
JCRAHWHSZYCYEI-LSGRDSQZSA-N
InChi Code
InChI=1S/C19H24N6O5S2.H2O4S/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11;1-5(2,3)4/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29);(H2,1,2,3,4)/b23-12-;/t13-,17-;/m1./s1
SMILES Code
O=C(C(N12)=C(C[N+]3(C)CCCC3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)[O-].O=S(O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 578.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kummer M, Šestáková N, Theurillat R, Huynh-Do U, Endimiani A, Sendi P, Thormann W. Monitoring of cefepime in urine by micellar electrokinetic capillary chromatography with ultraviolet detection and liquid chromatography coupled to mass spectrometry. J Sep Sci. 2018 Nov;41(21):4067-4074. doi: 10.1002/jssc.201800763. Epub 2018 Sep 25. PMID: 30198147. 2: So W, Kim L, Thabit AK, Nicolau DP, Kuti JL. Physical compatibility of isavuconazonium sulfate with select i.v. drugs during simulated Y-site administration. Am J Health Syst Pharm. 2017 Jan 1;74(1):e55-e63. doi: 10.2146/ajhp150733. Epub 2016 Dec 22. PMID: 28007722. 3: Guglick MA, MacAllister CG, Clarke CR, Pollet R, Hague C, Clarke JM. Pharmacokinetics of cefepime and comparison with those of ceftiofur in horses. Am J Vet Res. 1998 Apr;59(4):458-63. PMID: 9563631. 4: Yang YH, Wu WY, Yeh HH, Chen SH. Simultaneous determination of cefepime and vancomycin in plasma and cerebrospinal fluid by MEKC with direct sample injection and application for bacterial meningitis. Electrophoresis. 2007 Jun;28(11):1788-97. doi: 10.1002/elps.200600537. PMID: 17465423. 5: Musiał W, Zajac M. Stability of cefepime dihydrochloride monohydrate in solid state. Acta Pol Pharm. 2002 Jul-Aug;59(4):243-6. PMID: 12403297. 6: Karumathil DP, Yin HB, Kollanoor-Johny A, Venkitanarayanan K. Prevalence of Multidrug-Resistant Bacteria on Fresh Vegetables Collected from Farmers' Markets in Connecticut. J Food Prot. 2016 Aug;79(8):1446-51. doi: 10.4315/0362-028X.JFP-15-548. PMID: 27497135. 7: Papp-Wallace KM, Nguyen NQ, Jacobs MR, Bethel CR, Barnes MD, Kumar V, Bajaksouzian S, Rudin SD, Rather PN, Bhavsar S, Ravikumar T, Deshpande PK, Patil V, Yeole R, Bhagwat SS, Patel MV, van den Akker F, Bonomo RA. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J Med Chem. 2018 May 10;61(9):4067-4086. doi: 10.1021/acs.jmedchem.8b00091. Epub 2018 Apr 20. PMID: 29627985; PMCID: PMC6131718. 8: Schlesser V, Hecq JD, Vanbeckbergen D, Jamart J, Galanti LM. Effect of freezing, long-term storage, and microwave thawing on the stability of cefepime in 5% dextrose infusion polyvinyl chloride bags. Int J Pharm Compd. 2002 Sep- Oct;6(5):391-4. PMID: 23979419. 9: Jagadeesh Kumar V, Badarinadh Gupta P, Pavan Kumar KS, Prasada Rao KV, Rao KR, Prasanna SJ, Kumar Sharma H, Mukkanti K. Identification and characterization of new degradation products of cefepime dihydrochloride monohydrate drug substance during stress stability studies. Anal Sci. 2010;26(10):1081-6. doi: 10.2116/analsci.26.1081. PMID: 20953052. 10: Karr JC, Lauretta J, Keriazes G. In vitro antimicrobial activity of calcium sulfate and hydroxyapatite (Cerament Bone Void Filler) discs using heat- sensitive and non-heat-sensitive antibiotics against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. J Am Podiatr Med Assoc. 2011 Mar-Apr;101(2):146-52. doi: 10.7547/1010146. PMID: 21406698.