Cefditoren free base | CAS# 104145-95-1 (free base) | broad-spectrum antibiotic

MedKoo Cat#: 412506 | Name: Cefditoren free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefditoren free base is a broad-spectrum antibiotic, taken by mouth to treat pneumonia and other infections.

Chemical Structure

Cefditoren free base

CAS#104145-95-1 (free base)

Theoretical Analysis

MedKoo Cat#: 412506

Name: Cefditoren free base

CAS#: 104145-95-1 (free base)

Chemical Formula: C19H18N6O5S3

Exact Mass: 506.0501

Molecular Weight: 506.57

Elemental Analysis: C, 45.05; H, 3.58; N, 16.59; O, 15.79; S, 18.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

104146-53-4 (sodium) 104145-95-1 (free base) 117467-28-4 (pivoxil) 442852-27-9 (tosylate) 442852-31-5 (oxalate) 442852-33-7 (sulfate) 1448435-17-3 (pivoxil HCl) 442852-29-1 (mesylate)

Synonym

Cefditoren; UNII-81QS09V3YW

IUPAC/Chemical Name

(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((Z)-2-(4-methylthiazol-5-yl)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

InChi Key

KMIPKYQIOVAHOP-YLGJWRNMSA-N

InChi Code

InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14(9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13-,17-/m1/s1

SMILES Code

O=C(C(N12)=C(/C=C\C3=C(C)N=CS3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 506.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Giménez MJ, Aguilar L, Granizo JJ. Revisiting cefditoren for the treatment of community-acquired infections caused by human-adapted respiratory pathogens in adults. Multidiscip Respir Med. 2018 Nov 2;13:40. doi: 10.1186/s40248-018-0152-5. PMID: 30410757; PMCID: PMC6214181. 2: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Cefditoren. 2018 Oct 31. PMID: 30000384. 3: Sánchez Artola B, Barberán J. Cefditoreno: una realidad para el tratamiento de las infecciones comunitarias [Cefditoren: a reality for the treatment of community infections]. Rev Esp Quimioter. 2017 Dec;30(6):407-412. Spanish. Epub 2017 Dec 4. PMID: 29199418. 4: Darkes MJ, Plosker GL. Cefditoren pivoxil. Drugs. 2002;62(2):319-36; discussion 337-8. doi: 10.2165/00003495-200262020-00006. PMID: 11817976. 5: Soriano F, Giménez MJ, Aguilar L. Cefditoren in upper and lower community- acquired respiratory tract infections. Drug Des Devel Ther. 2011 Feb 9;5:85-94. doi: 10.2147/DDDT.S9499. PMID: 21340042; PMCID: PMC3038999. 6: Balbisi EA. Cefditoren, a new aminothiazolyl cephalosporin. Pharmacotherapy. 2002 Oct;22(10):1278-93. doi: 10.1592/phco.22.15.1278.33481. PMID: 12389878. 7: Jones RN, Pfaller MA, Jacobs MR, Appelbaum PC, Fuchs PC. Cefditoren in vitro activity and spectrum: a review of international studies using reference methods. Diagn Microbiol Infect Dis. 2001 Sep-Oct;41(1-2):1-14. doi: 10.1016/s0732-8893(01)00274-7. PMID: 11687308. 8: Guay DR. Review of cefditoren, an advanced-generation, broad-spectrum oral cephalosporin. Clin Ther. 2001 Dec;23(12):1924-37; discussion 1923. doi: 10.1016/s0149-2918(01)80147-8. PMID: 11813929. 9: Di Marco F, Braido F, Santus P, Scichilone N, Blasi F. The role of cefditoren in the treatment of lower community-acquired respiratory tract infections (LRTIs): from bacterial eradication to reduced lung inflammation and epithelial damage. Eur Rev Med Pharmacol Sci. 2014;18(3):321-32. PMID: 24563430. 10: Barberán J, Mensa J. Cefditoren en las infecciones de vías respiratorias bajas adquiridas en la comunidad [Cefditoren and community-acquired lower respiratory tract infections (corrected)]. Rev Esp Quimioter. 2009 Sep;22(3):144-50. Spanish. Erratum in: Rev Esp Quimioter. 2011 Mar;24(1):56. PMID: 19662548.