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MedKoo Cat#: 463425 | Name: BNTX Maleate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BNTX Maleate is a selective delta 1 opioid receptor antagonist. It also inhibits neurogenic ion transport mediated by a putative novel opioid receptor in porcine ileal mucosa.

Chemical Structure

BNTX Maleate
BNTX Maleate
CAS#129468-28-6

Theoretical Analysis

MedKoo Cat#: 463425

Name: BNTX Maleate

CAS#: 129468-28-6

Chemical Formula: C31H31NO8

Exact Mass: 545.2050

Molecular Weight: 545.59

Elemental Analysis: C, 68.25; H, 5.73; N, 2.57; O, 23.46

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Related CAS #
129468-28-6 864461-31-4
Synonym
BNTX Maleate; BNTX-Maleate;
IUPAC/Chemical Name
(4R,4aS,7aR,12bS)-6-((Z)-benzylidene)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one maleate
InChi Key
GKHUUKGUNNYVGB-GBMVFOCESA-N
InChi Code
InChI=1S/C27H27NO4.C4H4O4/c29-20-9-8-18-13-21-27(31)14-19(12-16-4-2-1-3-5-16)23(30)25-26(27,22(18)24(20)32-25)10-11-28(21)15-17-6-7-17;5-3(6)1-2-4(7)8/h1-5,8-9,12,17,21,25,29,31H,6-7,10-11,13-15H2;1-2H,(H,5,6)(H,7,8)/b19-12-;2-1-/t21-,25+,26+,27-;/m1./s1
SMILES Code
O=C(/C(C1)=C\C2=CC=CC=C2)[C@H]3[C@]([C@]1(O)[C@H]4C5)(CCN4CC6CC6)C7=C5C=CC(O)=C7O3.O=C(O)/C=C\C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 545.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim SY, Park S, Yoo S, Rho JK, Jun ES, Chang S, Kim KK, Kim SC, Kim I. Downregulation of X-linked inhibitor of apoptosis protein by '7-Benzylidenenaltrexone maleate' sensitizes pancreatic cancer cells to TRAIL- induced apoptosis. Oncotarget. 2017 May 12;8(37):61057-61071. doi: 10.18632/oncotarget.17841. PMID: 28977846; PMCID: PMC5617406. 2: Fryer RM, Wang Y, Hsu AK, Gross GJ. Essential activation of PKC-delta in opioid-initiated cardioprotection. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1346-53. doi: 10.1152/ajpheart.2001.280.3.H1346. PMID: 11179083.