Cdri 85-287 | CAS# 130064-18-5 | antiestrogen and antiimplantation agent

MedKoo Cat#: 412480 | Name: Cdri 85-287

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cdri 85-287 is an antiestrogen and antiimplantation agent.

Chemical Structure

Cdri 85-287

CAS#130064-18-5

Theoretical Analysis

MedKoo Cat#: 412480

Name: Cdri 85-287

CAS#: 130064-18-5

Chemical Formula: C28H29NO2

Exact Mass: 411.2198

Molecular Weight: 411.55

Elemental Analysis: C, 81.72; H, 7.10; N, 3.40; O, 7.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Cdri 85-287; CDRI85/287; CDRI 85/287; CDRI-85/287

IUPAC/Chemical Name

Piperidine, 1-(2-(4-(3-phenyl-2H-1-benzopyran-2-yl)phenoxy)ethyl)-

InChi Key

DBHGMZQRJDUFGS-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H29NO2/c1-3-9-22(10-4-1)26-21-24-11-5-6-12-27(24)31-28(26)23-13-15-25(16-14-23)30-20-19-29-17-7-2-8-18-29/h1,3-6,9-16,21,28H,2,7-8,17-20H2

SMILES Code

N1(CCOC2=CC=C(C3C(C4=CC=CC=C4)=CC5=CC=CC=C5O3)C=C2)CCCCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 411.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sreenivasulu S, Singh MM, Dwivedi A, Setty BS, Kamboj VP. CDRI-85/287, a novel antiestrogen and antiimplantation agent: biological profile and interaction with the estrogen receptors in immature rat uterus. Contraception. 1992 Jan;45(1):81-92. doi: 10.1016/0010-7824(92)90144-i. PMID: 1591925. 2: Saxena R, Fatima I, Chandra V, Blesson CS, Kharkwal G, Hussain MK, Hajela K, Roy BG, Dwivedi A. Benzopyran derivative CDRI-85/287 induces G2-M arrest in estrogen receptor-positive breast cancer cells via modulation of estrogen receptors α- and β-mediated signaling, in parallel to EGFR signaling and suppresses the growth of tumor xenograft. Steroids. 2013 Nov;78(11):1071-86. doi: 10.1016/j.steroids.2013.07.004. Epub 2013 Jul 26. PMID: 23891847. 3: Dwivedi A, Gupta G, Keshri G, Dhar JD. Changes in uterine ornithine decarboxylase activity and steroid receptor levels during decidualization in the rat induced by CDRI-85/287. Eur J Endocrinol. 1999 Oct;141(4):426-30. doi: 10.1530/eje.0.1410426. PMID: 10526259. 4: Sreenivasulu S, Singh MM, Setty BS, Kamboj VP. Effect of a pure nonsteroidal antiestrogen, CDRI-85/287, on implantation--associated histological and biochemical changes in the rat uterus. Contraception. 1993 Dec;48(6):597-609. doi: 10.1016/0010-7824(93)90121-m. PMID: 7510597. 5: Sreenivasulu S, Singh MM, Dwivedi A, Setty BS, Kamboj VP. Duration of antiestrogenecity of compound CDRI-85/287: a new orally active nonsteroidal antiimplantation agent. Indian J Exp Biol. 1992 Nov;30(11):968-71. PMID: 1293041. 6: Dwivedi A, Bansode FW, Setty BS, Dhar JD. Endometrial steroid receptors during decidualization in rhesus monkey (Macaca mulatta); their modulation by anti-oestrogen CDRI-85/287. Hum Reprod. 1999 Apr;14(4):1090-5. doi: 10.1093/humrep/14.4.1090. PMID: 10221246. 7: Gupta S, Dhar JD, Bansode FW, Setty BS. Effect of CDRI-85/287, a potent antiimplantation agent on uterine endometrial dimensions and peroxidase levels in rat. Indian J Exp Biol. 1998 May;36(5):464-9. PMID: 9717463. 8: Sreenivasulu S, Singh MM, Kamboj VP. Effect of a new anti-oestrogen and anti- implantation agent, CDRI-85/287, on tubal transport, development and viability of rat embryos. Reprod Fertil Dev. 1994;6(2):241-6. doi: 10.1071/rd9940241. PMID: 7991794. 9: Sreenivasulu S, Dwivedi A, Singh MM, Setty BS, Kamboj VP. CDRI-85/287: studies on competition to estrogen binding sites in the immature rat uterus. Indian J Exp Biol. 1992 Dec;30(12):1115-7. PMID: 1294475. 10: Lal J, Gupta RC. Liquid chromatographic determination of a non-steroidal oral contraceptive CDRI-85/287 in rat serum. J Pharm Biomed Anal. 1998 Jul;17(3):533-8. doi: 10.1016/s0731-7085(97)00231-8. PMID: 9656166.