Asoxime chloride monohydrate | CAS# 82504-20-9 | Biochemical

MedKoo Cat#: 575064 | Name: Asoxime chloride monohydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Asoxime, also known as HI-6, is an oxime reactivator used for counteracting intoxication by nerve agents. It is able to reactivate acetylcholinesterase (AChE) inhibited by cytotoxic nerve agents such as sarin or soman. AChE is a primary target of organophosphates, which inactivate it by reacting with the active center serine. This prevents the hydrolysis of acetylcholine at peripheral and central synapses. Asoxime reactivates phosphorylated AChE that has been inhibited by exposure to cytotoxic nerve agents.

Chemical Structure

Asoxime chloride monohydrate

CAS#82504-20-9 (chloride hydrate)

Theoretical Analysis

MedKoo Cat#: 575064

Name: Asoxime chloride monohydrate

CAS#: 82504-20-9 (chloride hydrate)

Chemical Formula: C14H18Cl2N4O4

Exact Mass: 376.0705

Molecular Weight: 377.22

Elemental Analysis: C, 44.58; H, 4.81; Cl, 18.80; N, 14.85; O, 16.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

34433-31-3 (chloride) 144252-71-1 (mesylate) 82504-20-9 (chloride hydrate)

Synonym

Asoxime chloride monohydrate

IUPAC/Chemical Name

Pyridinium, 1-(((4-(aminocarbonyl)pyridinio)methoxy)methyl)-2-((hydroxyimino)methyl)-, chloride, hydrate (1:2:1)

InChi Key

GYEZCRHNOKYBFX-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H14N4O3.2ClH.H2O/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;;/h1-9H,10-11H2,(H-,15,19);2*1H;1H2

SMILES Code

O.[Cl-].[Cl-].NC(=O)c1cc[n+](COC[n+]2ccccc2\C=N\O)cc1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 377.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mann TM, Price ME, Whitmore CL, Perrott RL, Laws TR, McColm RR, Emery ER, Tattersall JEH, Green AC, Rice H. Bioscavenger is effective as a delayed therapeutic intervention following percutaneous VX poisoning in the guinea-pig. Toxicol Lett. 2018 Sep 1;293:198-206. doi: 10.1016/j.toxlet.2017.11.029. Epub 2017 Nov 26. PubMed PMID: 29183815. 2: Whitmore C, Cook AR, Mann T, Price ME, Emery E, Roughley N, Flint D, Stubbs S, Armstrong SJ, Rice H, Tattersall JEH. The efficacy of HI-6 DMS in a sustained infusion against percutaneous VX poisoning in the guinea-pig. Toxicol Lett. 2018 Sep 1;293:207-215. doi: 10.1016/j.toxlet.2017.11.007. Epub 2017 Nov 10. PubMed PMID: 29129798. 3: Worek F, Koller M, Thiermann H, Wille T. Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. Toxicology. 2016 Mar 28;350-352:25-30. doi: 10.1016/j.tox.2016.05.001. Epub 2016 May 3. PubMed PMID: 27153754.