Mitoglitazone R-isomer is the R-isomer of Mitoglitazone, which is also known as CAY10415. Mitoglitazone is a novel peroxisome proliferator-activated receptor (PPAR)γ ligand. CAY10415 induced cell death and ROS generation in a PPARγ-independent manner. CAY10415 enhanced γ-radiation-induced apoptosis and caspase-3-mediated poly (ADP-ribose) polymerase (PARP) cleavage in vitro. The combined CAY10415 / γ-radiation treatment triggered caspase-8 activation, and this initiator caspase played an important role in the combination-induced apoptosis. The combined treatment of CAY10415 and γ-radiation synergistically induced DNA damage and apoptosis, which was regulated by ROS.
MedKoo Cat#: 412460
Name: Mitoglitazone R-isomer
CAS#: 1628078-14-7 (R-isomer)
Chemical Formula: C19H18N2O4S
Exact Mass: 370.0987
Molecular Weight: 370.42
Elemental Analysis: C, 61.61; H, 4.90; N, 7.56; O, 17.28; S, 8.65
The following data is based on the product molecular weight 370.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
