Synonym
Articaine (free base), HOE045, HOE-045, HOE 045
IUPAC/Chemical Name
4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid, methyl ester
InChi Key
QTGIAADRBBLJGA-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H20N2O3S/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4/h7,9,14H,5-6H2,1-4H3,(H,15,16)
SMILES Code
O=C(C1=C(NC(C(NCCC)C)=O)C(C)=CS1)OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
284.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Yeung V. Articaine--to use or not to use? SAAD Dig. 2016 Jan;32:50-4. Review. PubMed PMID: 27145561.
3: Su N, Li C, Wang H, Shen J, Liu W, Kou L. Efficacy and safety of articaine versus lidocaine for irreversible pulpitis treatment: A systematic review and meta-analysis of randomised controlled trials. Aust Endod J. 2016 Apr;42(1):4-15. doi: 10.1111/aej.12125. Review. PubMed PMID: 27062318.
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7: Kakroudi SH, Mehta S, Millar BJ. Articaine hydrochloride: is it the solution? Dent Update. 2015 Jan-Feb;42(1):88-90, 92-3. Review. PubMed PMID: 26062283.
8: Brockmann WG. Mepivacaine: a closer look at its properties and current utility. Gen Dent. 2014 Nov-Dec;62(6):70-5; quiz 76. Review. PubMed PMID: 25369391.
9: Förster JG. Short-acting spinal anesthesia in the ambulatory setting. Curr Opin Anaesthesiol. 2014 Dec;27(6):597-604. doi: 10.1097/ACO.0000000000000126. Review. PubMed PMID: 25211156.
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15: Powell V. Articaine is superior to lidocaine in providing pulpal anesthesia. J Am Dent Assoc. 2012 Aug;143(8):897-8. Review. PubMed PMID: 22855904.
16: Becker DE, Reed KL. Local anesthetics: review of pharmacological considerations. Anesth Prog. 2012 Summer;59(2):90-101; quiz 102-3. doi: 10.2344/0003-3006-59.2.90. Review. PubMed PMID: 22822998; PubMed Central PMCID: PMC3403589.
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