Synonym
Cartap (free base); T1258; T 1258; T-1258
IUPAC/Chemical Name
S,S'-(2-(dimethylamino)propane-1,3-diyl) dicarbamothioate
InChi Key
IRUJZVNXZWPBMU-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H15N3O2S2/c1-10(2)5(3-13-6(8)11)4-14-7(9)12/h5H,3-4H2,1-2H3,(H2,8,11)(H2,9,12)
SMILES Code
CN(C(CSC(N)=O)CSC(N)=O)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
237.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wu M, Deng H, Fan Y, Hu Y, Guo Y, Xie L. Rapid Colorimetric Detection of Cartap Residues by AgNP Sensor with Magnetic Molecularly Imprinted Microspheres as Recognition Elements. Molecules. 2018 Jun 14;23(6):1443. doi: 10.3390/molecules23061443. PMID: 29899218; PMCID: PMC6099834.
2: Sharma LP, Kadve MP, Lingaraju MC, Telang AG. Studies on oral subacute toxicity of cartap in male mice. Drug Chem Toxicol. 2019 Jan 7:1-9. doi: 10.1080/01480545.2018.1551900. Epub ahead of print. PMID: 30614290.
3: Kalyaniwala K, Abhilash K, Victor PJ. Cartap Hydrochloride Poisoning. J Assoc Physicians India. 2016 Aug;64(8):91-92. PMID: 27762121.
4: Dai J, Chen H, Gao G, Zhu L, Chai Y, Liu X. Simultaneous determination of cartap and its metabolite in tea using hydrophilic interaction chromatography tandem mass spectrometry and the combination of dispersive solid phase extraction and solid phase extraction. J Chromatogr A. 2019 Aug 30;1600:148-157. doi: 10.1016/j.chroma.2019.04.034. Epub 2019 Apr 13. PMID: 31060785.
5: Emadi M, Maghami P, Khorsandi K, Hosseinzadeh R. Biophysical study on the interaction of cartap hydrochloride and hemoglobin: Heme degradation and functional changes of protein. J Biochem Mol Toxicol. 2019 Jul;33(7):e22325. doi: 10.1002/jbt.22325. Epub 2019 Apr 20. PMID: 31004546.
6: Dong L, Hou C, Fa H, Yang M, Wu H, Zhang L, Huo D. Highly Sensitive Fluorescent Sensor for Cartap Based on Fluorescence Resonance Energy Transfer Between Gold Nanoparticles and Rhodamine B. J Nanosci Nanotechnol. 2018 Apr 1;18(4):2441-2449. doi: 10.1166/jnn.2018.14283. PMID: 29442913.
7: Gupta VK, Siddiqi NJ, Ojha AK, Sharma B. Hepatoprotective effect of Aloe vera against cartap- and malathion-induced toxicity in Wistar rats. J Cell Physiol. 2019 Aug;234(10):18329-18343. doi: 10.1002/jcp.28466. Epub 2019 Mar 19. PMID: 30891764.
8: Liao JW, Kang JJ, Jeng CR, Chang SK, Kuo MJ, Wang SC, Liu MR, Pang VF. Cartap-induced cytotoxicity in mouse C2C12 myoblast cell line and the roles of calcium ion and oxidative stress on the toxic effects. Toxicology. 2006 Feb 15;219(1-3):73-84. doi: 10.1016/j.tox.2005.11.002. Epub 2005 Dec 2. PMID: 16325978.
9: Boorugu HK, Chrispal A. Cartap hydrochloride poisoning: A clinical experience. Indian J Crit Care Med. 2012 Jan;16(1):58-9. doi: 10.4103/0972-5229.94443. PMID: 22557838; PMCID: PMC3338244.
10: Zhou S, Dong Q, Li S, Guo J, Wang X, Zhu G. Developmental toxicity of cartap on zebrafish embryos. Aquat Toxicol. 2009 Dec 13;95(4):339-46. doi: 10.1016/j.aquatox.2009.10.006. Epub 2009 Nov 1. PMID: 19923012.
