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MedKoo Cat#: 575009 | Name: Arimoclomol citrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arimoclomol citrate is a heat shock protein amplifier potentially useful for the treatment of Niemann-Pick disease type C (NP-C). Arimoclomol is believed to function by stimulating a normal cellular protein repair pathway through the activation of molecular chaperones.

Chemical Structure

Arimoclomol citrate
Arimoclomol citrate
CAS#368860-21-3 (citrate)

Theoretical Analysis

MedKoo Cat#: 575009

Name: Arimoclomol citrate

CAS#: 368860-21-3 (citrate)

Chemical Formula: C20H28ClN3O10

Exact Mass: 505.1463

Molecular Weight: 505.90

Elemental Analysis: C, 47.48; H, 5.58; Cl, 7.01; N, 8.31; O, 31.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
289893-25-0 (free base) 289893-26-1 (maleate) 368860-21-3 (citrate)
Synonym
Arimoclomol citrate; BRX-220; BRX 220; BRX220; BRX-345; BRX 345; BRX345;
IUPAC/Chemical Name
3-Pyridinecarboximidoyl chloride, N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-, 1-oxide, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
InChi Key
XSENLDLUMVYRET-BTQNPOSSSA-N
InChi Code
InChI=1S/C14H20ClN3O3.C6H8O7/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-5,8-9,13,19H,1-3,6-7,10-11H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t13-;/m1./s1
SMILES Code
O[C@@H](CON=C(Cl)c1ccc[n+]([O-])c1)CN2CCCCC2.OC(=O)CC(O)(CC(=O)O)C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 505.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: McDermott CJ. Clinical trials in amyotrophic lateral sclerosis. Curr Opin Neurol. 2019 Oct;32(5):758-763. doi: 10.1097/WCO.0000000000000731. PubMed PMID: 31335338. 2: Hettinghouse A, Liu CJ. Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models. EBioMedicine. 2018 Dec;38:7-8. doi: 10.1016/j.ebiom.2018.11.052. Epub 2018 Dec 3. PubMed PMID: 30522930; PubMed Central PMCID: PMC6306393. 3: Fog CK, Zago P, Malini E, Solanko LM, Peruzzo P, Bornaes C, Magnoni R, Mehmedbasic A, Petersen NHT, Bembi B, Aerts JFMG, Dardis A, Kirkegaard T. The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase. EBioMedicine. 2018 Dec;38:142-153. doi: 10.1016/j.ebiom.2018.11.037. Epub 2018 Nov 27. PubMed PMID: 30497978; PubMed Central PMCID: PMC6306395.