Synonym
Carocainide; BRN5154193; BRN-5154193; BRN 5154193; Carocainidum
IUPAC/Chemical Name
1-(4,7-Dimethoxy-6-(2-(1-pyrrolidinyl)ethoxy)-5-benzofuranyl)-3-methylurea
InChi Key
BWMMRMDCODVQBX-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H25N3O5/c1-19-18(22)20-13-14(23-2)12-6-10-25-15(12)17(24-3)16(13)26-11-9-21-7-4-5-8-21/h6,10H,4-5,7-9,11H2,1-3H3,(H2,19,20,22)
SMILES Code
O=C(NC)NC1=C(OCCN2CCCC2)C(OC)=C(OC=C3)C3=C1OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
363.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Rovei V, Strolin Benedetti M, Daniel C, Moulin A, Donath A. Pharmacokinetics and metabolism of the anti-arrhythmic carocainide in man. Xenobiotica. 1985 Nov;15(11):953-64. doi: 10.3109/00498258509045048. PMID: 4082635.
2: Muramoto J, Hotokebuchi N, Nishi K. Effect of an antiarrhythmic agent, carocainide, on action potentials of ventricular papillary muscle of the guinea- pig heart in vitro. Arch Int Pharmacodyn Ther. 1991 Jul-Aug;312:27-38. PMID: 1772338.
3: Bach P, Steinbeck G. Electrophysiologic and antiarrhythmic effects of carocainide in humans. J Cardiovasc Pharmacol. 1988 Dec;12(6):637-42. doi: 10.1097/00005344-198812000-00003. PMID: 2467080.
4: Zannad F, Aliot E, Baille N, Gilgenkrantz JM. Effets électrophysiologiques du carocaïnide intraveineux [Electrophysiologic effects of intravenous carocainide]. Arch Mal Coeur Vaiss. 1986 Feb;79(2):236-41. French. PMID: 3085623.
5: Huerta F, Pourrias B. Effects of carocainide (770207) on canine cardiac automaticity. Arch Int Pharmacodyn Ther. 1984 Apr;268(2):216-24. PMID: 6732365.
6: Pourrias B, Huerta F, Santamaria R, Tisne Versailles J. Effects of MD770207 (carocainide) on experimental ventricular arrhythmias. Arch Int Pharmacodyn Ther. 1983 May;263(1):85-102. PMID: 6615084.
7: Pourrias B, Santamaria R. Electrophysiological effects of carocainide (770207) on canine ventricular muscle and Purkinje fibers. Arch Int Pharmacodyn Ther. 1983 Sep;265(1):85-95. PMID: 6316863.
8: Huerta F, Santamaria R, Pourrias B. Electrophysiological effects of carocainide (770207) on the dog heart. Arch Int Pharmacodyn Ther. 1984 Feb;267(2):289-98. PMID: 6712362.
