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MedKoo Cat#: 463775 | Name: 7-Xylosyltaxol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

7-Xylosyltaxol is a taxane and derivative of paclitaxel that has been found in T. chinensis and has microtubule disruptor and anticancer activities. It induces the disassembly of pig brain and Physarum microtubules in cell-free assays. 7-Xylosyltaxol inhibits proliferation of A549, MCF-7, A2780, HCT-8, and SW480 cancer cells with IC50 values of 0.39, 0.16, 0.85, 5.9, and 5.6 µM, respectively.

Chemical Structure

7-Xylosyltaxol
7-Xylosyltaxol
CAS#90332-66-4

Theoretical Analysis

MedKoo Cat#: 463775

Name: 7-Xylosyltaxol

CAS#: 90332-66-4

Chemical Formula: C52H59NO18

Exact Mass: 985.3732

Molecular Weight: 986.03

Elemental Analysis: C, 63.34; H, 6.03; N, 1.42; O, 29.21

Price and Availability

Size Price Availability Quantity
1mg USD 650.00 2 Weeks
5mg USD 1,650.00 2 Weeks
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Related CAS #
No Data
Synonym
7-Xylosyltaxol; 7 Xylosyltaxol;
IUPAC/Chemical Name
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate
InChi Key
ZVEGOBHUZTXSFK-TZIKQHFSSA-N
InChi Code
InChI=1S/C52H59NO18/c1-26-33(68-47(63)39(58)37(29-16-10-7-11-17-29)53-45(61)30-18-12-8-13-19-30)23-52(64)44(70-46(62)31-20-14-9-15-21-31)42-50(6,43(60)41(67-27(2)54)36(26)49(52,4)5)34(22-35-51(42,25-66-35)71-28(3)55)69-48-40(59)38(57)32(56)24-65-48/h7-21,32-35,37-42,44,48,56-59,64H,22-25H2,1-6H3,(H,53,61)/t32-,33+,34+,35-,37+,38+,39-,40-,41-,42+,44+,48+,50-,51+,52-/m1/s1
SMILES Code
C[C@@]1([C@@]([H])([C@@](CO2)(OC(C)=O)[C@]2(C[C@@H]1O[C@@]([H])([C@H](O)[C@H]3O)OC[C@H]3O)[H])[C@@H]4OC(C5=CC=CC=C5)=O)C([C@H](OC(C)=O)C6=C([C@H](C[C@@]4(C6(C)C)O)OC([C@@H]([C@@H](NC(C7=CC=CC=C7)=O)C8=CC=CC=C8)O)=O)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 986.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yusakul G, Sakamoto S, Tanaka H, Morimoto S. Efficient expression of single chain variable fragment antibody against paclitaxel using the Bombyx mori nucleopolyhedrovirus bacmid DNA system and its characterizations. J Nat Med. 2016 Jul;70(3):592-601. doi: 10.1007/s11418-016-0981-5. Epub 2016 Mar 3. PMID: 26940321. 2: Yu SS, Sun QW, Zhang XP, Tian SN, Bo PL. [Content and distribution of active components in cultivated and wild Taxus chinensis var. mairei plants]. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. Chinese. PMID: 23359921. 3: Chao Z, Tan M, Paudel MK, Sakamoto S, Ma L, Sasaki-Tabata K, Tanaka H, Shoyama Y, Xuan L, Morimoto S. Development of an indirect competitive enzyme- linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel. J Nat Med. 2013 Jul;67(3):512-8. doi: 10.1007/s11418-012-0708-1. Epub 2012 Sep 25. PMID: 23007175.