Synonym
Cardioplegin; Magnesium aspartate, mixted with procaine hydrochloride
IUPAC/Chemical Name
Magnesate(2-), bis(L-aspartato(2-)-N,O1)-, (T-4)-, dihydrogen, mixt. with 2-(diethylamino)ethyl 4-aminobenzoate monohydrochloride
InChi Key
GRAMCUGYYSXQQQ-UHFFFAOYSA-L
InChi Code
InChI=1S/C13H20N2O2.2C4H7NO4.ClH.Mg/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;2*5-2(4(8)9)1-3(6)7;;/h5-8H,3-4,9-10,14H2,1-2H3;2*2H,1,5H2,(H,6,7)(H,8,9);1H;/q;;;;+2/p-2
SMILES Code
CCN(CCOC(c1ccc(N)cc1)=O)CC.NC(C([O-])=O)CC([O-])=O.NC(C([O-])=O)CC([O-])=O.[H+].[H+].[Mg+2].Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
561.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kalmár P, Bleese N, Döring V, Gercken G, Kirsch U, Lierse W, Pokar H, Polonius MJ, Rodewald G. Induced ischemic cardiac arrest. Clinical and experimental results with magnesium-aspartate-procaine solution (Cardioplegin). J Cardiovasc Surg (Torino). 1975 Sep-Oct;16(5):470-5. PMID: 1194331.
2: Hoffmeister HE, Seboldt H, Seybold-Epting W, Stunkat R. Myokardschutz mit Hypothermie und Cardioplegin bei der Operation angeborener Herzfehler [Myocardial protection utilizing hypothermia and cardioplegin during surgical correction of congenital heart disease (author's transl)]. Thoraxchir Vask Chir. 1978 Apr;26(2):98-103. German. doi: 10.1055/s-0028-1096604. PMID: 653708.
3: Dragoĭchev Ch, Daskalov E, Konstantinov P, Madzharov D. Pŭrvi rezultati ot prilozhenieto kardioplegin pri sŭrdechni operatsii [Initial results of using Cardioplegin in heart operations]. Khirurgiia (Sofiia). 1981;34(1):13-20. Bulgarian. PMID: 7230657.
4: Lorkiewicz Z, Borzycka B, Ponizyński A, Blotna-Filipiak M. Przydatność cardiopleginy do operacji w krazeniu pozaustrojowym [Usefulness of Cardioplegin in surgery with extracorporeal circulation]. Kardiol Pol. 1973;16(4):299-307. Polish. PMID: 4756964.
5: Walpoth B, Fornaro M, von Gossler W, Turina M. Tierexperimentelle Beurteilung des Myokardschutzes mittels Magnesium-asparaginat-procain-Lösung [Animal experiment evaluation of myocardial protection with a magnesium-asparaginate- procaine solution]. Chir Forum Exp Klin Forsch. 1978;(1978):99-102. German. PMID: 752612.
6: Isselhard W, Schorn B, Hügel W, Uekermann U. Comparison of three methods of myocardial protection. Thorac Cardiovasc Surg. 1980 Oct;28(5):329-36. doi: 10.1055/s-2007-1022103. PMID: 6161431.
7: Regensburger D, Hellberg K, Knoll D, Ruschewski W, Schenk HD, Sonntag H, de Vivie R, Wolfram-Donath U. Koronardurchblutung und myokardialer Sauerstoffverbrauch nach künstlichem Herzstillstand [Coronary circulation and myocardial oxygen cosumption after cardioplegic arrest (author's transl)]. Thoraxchir Vask Chir. 1975 Jun;23(3):306-8. German. doi: 10.1055/s-0028-1096969. PMID: 1080609.
8: Isselhard W, Schorn B, Uekermann U, Hügel W. Myokardialer Stoffwechselstatus bei verschiedenen Verfahren zur Einleitung eines reversiblen Herzstillstandes [Myocardial metabolic status in various methods of inducing a reversible heart arrest]. Chir Forum Exp Klin Forsch. 1979:29-32. German. PMID: 456143.
9: Weber DO, Yarnoz MD. Hyperkalemia complicating cardiopulmonary bypass: analysis of risk factors. Ann Thorac Surg. 1982 Oct;34(4):439-45. doi: 10.1016/s0003-4975(10)61407-5. PMID: 7138111.
10: Kugelberg J, Hägerdal M, Carlsson C. Myocardial protection during heart surgery. An experimental evaluation of normothermic and hypothermic cardioplegia. Scand J Thorac Cardiovasc Surg. 1979;13(1):47-52. doi: 10.3109/14017437909101786. PMID: 432573.
