MedKoo Cat#: 592596 | Name: Azacyclonol hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Azacyclonol hydrochloride is used in the treatment of chronic schizophrenia.

Chemical Structure

Azacyclonol hydrochloride
Azacyclonol hydrochloride
CAS#1798-50-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 592596

Name: Azacyclonol hydrochloride

CAS#: 1798-50-1 (HCl)

Chemical Formula: C18H22ClNO

Exact Mass: 303.1390

Molecular Weight: 303.83

Elemental Analysis: C, 71.16; H, 7.30; Cl, 11.67; N, 4.61; O, 5.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Azacyclonol hydrochloride; Azacyclonol HCl
IUPAC/Chemical Name
4-Piperidinemethanol, alpha,alpha-diphenyl-, hydrochloride
InChi Key
LBRAWKGGVUCSOX-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21NO.ClH/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17;/h1-10,17,19-20H,11-14H2;1H
SMILES Code
OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCNCC3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 303.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: BRAUN DL, BROWN BB, FELDMAN RG. The pharmacologic activity of alpha-(4-piperidyl)-benzhydrol hydrochloride (azacyclonol hydrochloride); an ataractive agent. J Pharmacol Exp Ther. 1956 Oct;118(2):153-61. PubMed PMID: 13368052. 2: ODLAND TM. Azacyclonol (frenquel) hydrochloride in the treatment of chronic schizophrenia; a double-blind, controlled study. J Am Med Assoc. 1957 Sep 28;165(4):333-5. PubMed PMID: 13462791. 3: DHAWAN BN, GUPTA GP. Hypothermic and antipyretic activity of 4-piperidyl diphenyl carbinol hydrochloride (azacyclonol). Arch Int Pharmacodyn Ther. 1962 May 1;137:54-60. PubMed PMID: 13885959. 4: TRAVIS JC. Treatment of the acute complications of chronic alcoholism; use of azacyclonol (frenquel) hydrochloride in one hundred consecutive cases. J Am Med Assoc. 1958 May 10;167(2):156-7. PubMed PMID: 13538682. 5: BEN-DAVID M, MENCZEL E, SULMAN FG. THE HYPOGLYCAEMIC EFFECT OF AZACYCLONOL AND ITS MECHANISM. Arch Int Pharmacodyn Ther. 1963 Oct 1;145:309-21. PubMed PMID: 14067559. 6: HERVE Y, CARRIE J, GAYRAL L, LE MAILLOUX. [Azacyclonol (Frenquel). Uses and results]. Toulouse Med. 1960 Oct;61:663-8. French. PubMed PMID: 13713843. 7: COATS EA, GRAY RW, MACQUIDDY EL. The use of azacyclonol (frenquel) in the treatment of mental disturbances of the aged: a double-blind, controlled study. J Am Geriatr Soc. 1958 Sep;6(9):675-80. PubMed PMID: 13575102. 8: LEVY S. Intravenous use of azacyclonol. Northwest Med. 1958 May;57(5):620-3. PubMed PMID: 13541823. 9: BERRY JF, MAGEE WL, ROSSITER RJ. Effect of chlorpromazine and azacyclonol on the labelling of phosphatides in brain slices. Biochim Biophys Acta. 1956 Aug;21(2):408-9. PubMed PMID: 13363943. 10: SOULAIRAC A, HALPERN B, MOREL P, SCHAUB S. [Trial treatment of certain chronic hallucinatory psychotic syndromes by azacyclonol (frenquel)]. Ann Med Psychol (Paris). 1960 Apr;118(1):768-80. French. PubMed PMID: 13833008. 11: Martens J. Determination of the terfenadine metabolite azacyclonol in human serum using gas chromatography-mass spectrometry. J Chromatogr B Biomed Appl. 1996 Apr 12;678(2):349-53. PubMed PMID: 8738042. 12: RUMKE CL. [Pharmacological & clinical effects of azacyclonol]. Ned Tijdschr Geneeskd. 1958 Oct 18;102(42):2057-60. Dutch. PubMed PMID: 13613404. 13: ALLIN TG Jr, POGGE RC. The use of azacyclonol and pipradrol in general practice. Int Rec Med Gen Pract Clin. 1956 Apr;169(4):222-30. PubMed PMID: 13318734. 14: Kuhlman JJ Jr, Levine B, Klette KL, Magluilo J Jr, Kalasinsky KS, Smith ML. Measurement of azacyclonol in urine and serum of humans following terfenadine (Seldane) administration using gas chromatography-mass spectrometry. J Chromatogr. 1992 Jul 24;578(2):207-13. PubMed PMID: 1400799. 15: BENSOUSSAN P, VILLIAUMEY EM, ROUSSEAU J. [Symptomatic effects of azacyclonol on an hallucinatory and interpretative syndrome; presentation of patient]. Ann Med Psychol (Paris). 1956 May;114(5):821-5. French. PubMed PMID: 13340359. 16: LEMERE F. Failure of azacyclonol (frenquel) to relieve non-experimental mental confusion and hallucinations. Am J Psychiatry. 1957 Mar;113(9):840-1. PubMed PMID: 13402977. 17: DRESEL PE. The effect of azacyclonol on some cardiovascular and metabolic actions of epinephrine. J Pharmacol Exp Ther. 1959 Mar;125(3):208-12. PubMed PMID: 13642259. 18: [Azacyclonol (chlorhydrate). Chlorhydrate of diphenyl (4-piperidyl) methanol]. Ann Pharm Fr. 1968 Jul-Aug;26(7):583-4. French. PubMed PMID: 5729721. 19: Ling KH, Leeson GA, Burmaster SD, Hook RH, Reith MK, Cheng LK. Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes. Drug Metab Dispos. 1995 Jun;23(6):631-6. PubMed PMID: 7587944. 20: FERGUSON JT. Azacyclonol: use of a new pharmacologic agent in chronic schizophrenia. Antibiotic Med Clin Ther (New York). 1956 Jul;3(2):146-51. PubMed PMID: 13340696.