Synonym
STING Agonist 12b; STING Agonist-12b;
IUPAC/Chemical Name
2-methoxy-5,6-dimethylacridin-9(10H)-one
InChi Key
SEVGTQHWWAYAQR-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15NO2/c1-9-4-6-12-15(10(9)2)17-14-7-5-11(19-3)8-13(14)16(12)18/h4-8H,1-3H3,(H,17,18)
SMILES Code
O=C1C2=CC=C(C(C)=C2NC3=CC=C(OC)C=C13)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
253.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hou S, Lan XJ, Li W, Yan XL, Chang JJ, Yang XH, Sun W, Xiao JH, Li S. Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists. Bioorg Chem. 2020 Jan;95:103556. doi: 10.1016/j.bioorg.2019.103556. Epub 2019 Dec 30. PMID: 31927317.
2: Liu, H., Liu, J., Chen, Y., Yang, H., Fang, J., Zeng, X., ... & Guo, Z. (2024). Development of STING probes and visualization of STING in multiple tumor types. European Journal of Nuclear Medicine and Molecular Imaging, 1-15.
