Synonym
Locustakinn; Lomk peptide; Ala-phe-ser-ser-trp-gly-NH2;
IUPAC/Chemical Name
(S)-N-(2-amino-2-oxoethyl)-2-((S)-2-((S)-2-((S)-2-((S)-2-aminopropanamido)-3-phenylpropanamido)-3-hydroxypropanamido)-3-hydroxypropanamido)-3-(1H-indol-3-yl)propanamide
InChi Key
YQZDDGVNOHGBSM-QAMDWANKSA-N
InChi Code
1S/C31H40N8O8/c1-17(32)27(43)36-22(11-18-7-3-2-4-8-18)29(45)38-25(16-41)31(47)39-24(15-40)30(46)37-23(28(44)35-14-26(33)42)12-19-13-34-21-10-6-5-9-20(19)21/h2-10,13,17,22-25,34,40-41H,11-12,14-16,32H2,1H3,(H2,33,42)(H,35,44)(H,36,43)(H,37,46)(H,38,45)(H,39,47)/t17-,22-,23-,24-,25-/m0/s1
SMILES Code
O=C([C@@H](NC([C@H](C)N)=O)Cc1ccccc1)N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(NCC(N)=O)=O)Cc2c3ccccc3[nH]c2)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
652.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Coast GM. Synergism between diuretic peptides controlling ion and fluid transport in insect malpighian tubules. Regul Pept. 1995 Jun 27;57(3):283-96. PubMed PMID: 7480878.
2: Schoofs L, Holman GM, Proost P, Van Damme J, Hayes TK, De Loof A. Locustakinin, a novel myotropic peptide from Locusta migratoria, isolation, primary structure and synthesis. Regul Pept. 1992 Jan 2;37(1):49-57. PubMed PMID: 1585017.
3: Thompson KS, Rayne RC, Gibbon CR, May ST, Patel M, Coast GM, Bacon JP. Cellular colocalization of diuretic peptides in locusts: a potent control mechanism. Peptides. 1995;16(1):95-104. PubMed PMID: 7716080.
4: Coast GM. The influence of neuropeptides on Malpighian tubule writhing and its significance for excretion. Peptides. 1998;19(3):469-80. PubMed PMID: 9533634.
5: Coast GM, Meredith J, Phillips JE. Target organ specificity of major neuropeptide stimulants in locust excretory systems. J Exp Biol. 1999 Nov;202 Pt 22:3195-203. PubMed PMID: 10539968.
6: Coast GM. Neuropeptides implicated in the control of diuresis in insects. Peptides. 1996;17(2):327-36. Review. PubMed PMID: 8801541.
7: Schoofs L, Veelaert D, Vanden Broeck J, De Loof A. Peptides in the locusts, Locusta migratoria and Schistocerca gregaria. Peptides. 1997;18(1):145-56. Review. PubMed PMID: 9114464.
8: Nässel DR. Insect myotropic peptides: differential distribution of locustatachykinin- and leucokinin-like immunoreactive neurons in the locust brain. Cell Tissue Res. 1993 Oct;274(1):27-40. PubMed PMID: 8242709.
