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MedKoo Cat#: 574974 | Name: Esuberaprost sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Esuberaprost sodium is a vasodilator that has been shown to bind to PGI2 receptors in smooth muscle cells and platelets in order to prevent the formation of blood clots and lower blood pressure in the lungs.

Chemical Structure

Esuberaprost sodium
Esuberaprost sodium
CAS#152695-53-9 (Na)

Theoretical Analysis

MedKoo Cat#: 574974

Name: Esuberaprost sodium

CAS#: 152695-53-9 (Na)

Chemical Formula: C24H29NaO5

Exact Mass: 420.1913

Molecular Weight: 420.48

Elemental Analysis: C, 68.56; H, 6.95; Na, 5.47; O, 19.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1416252-97-5 (K) 152695-53-9 (Na) 94132-88-4 (free base)
Synonym
Esuberaprost sodium; Beraprost sodium 314D, BPS-314D sodium, APS-314D sodium
IUPAC/Chemical Name
sodium 4-((1R,2R,3aS,8bS)-2-hydroxy-1-((3S,4S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate
InChi Key
YTCZZXIRLARSET-ZTWNIFTGSA-M
InChi Code
InChI=1S/C24H30O5.Na/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28;/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28);/q;+1/p-1/b13-12+;/t15-,17-,19+,20+,21-,23-;/m0./s1
SMILES Code
[Na+].CC#CC[C@H](C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2Oc3c(CCCC(=O)[O-])cccc3[C@H]12
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 420.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Shen L, Patel JA, Norel X, Moledina S, Whittle BJ, von Kessler K, Sista P, Clapp LH. Pharmacology of the single isomer, esuberaprost (beraprost-314d) on pulmonary vascular tone, IP receptors and human smooth muscle proliferation in pulmonary hypertension. Biochem Pharmacol. 2019 Aug;166:242-252. doi: 10.1016/j.bcp.2019.05.026. Epub 2019 May 31. PMID: 31158340.