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MedKoo Cat#: 463300 | Name: Ginsenoside F1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ginsenoside F1 (GF1) is a ginsenoside that has been found in P. ginseng and has diverse biological activities. It increases cytotoxic degranulation of natural killer (NK) cells against K562 leukemia cells in vitro when used at a concentration of 10 µM and enhances NK cell-mediated lymphoma clearance in vivo. GF1 reduces atherosclerotic lesion area, whole body myeloperoxidase (MPO) levels, and aortic root NF-kB, TLR4, and LOX-1 levels in ApoE-/- mice. It increases microvessel density and improves focal cerebral blood perfusion in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO). GF1 also restores spatial working memory, but not context-dependent fear memory, in the APP/PS1 transgenic mouse model of Alzheimer's disease.

Chemical Structure

Ginsenoside F1
Ginsenoside F1
CAS#53963-43-2

Theoretical Analysis

MedKoo Cat#: 463300

Name: Ginsenoside F1

CAS#: 53963-43-2

Chemical Formula: C36H62O9

Exact Mass: 638.4394

Molecular Weight: 638.88

Elemental Analysis: C, 67.68; H, 9.78; O, 22.54

Price and Availability

Size Price Availability Quantity
50mg USD 350.00 2 Weeks
100mg USD 550.00 2 Weeks
250mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Ginsenoside F1; Ginsenoside-F1; Panaxoside A progenin; 20(S)-Ginsenoside F1; F1 ginsenoside; GF1; GF 1; GF-1;
IUPAC/Chemical Name
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(((S)-6-methyl-2-((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,6,12-trihydroxy-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)hept-5-en-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triol
InChi Key
XNGXWSFSJIQMNC-FIYORUNESA-N
InChi Code
InChI=1S/C36H62O9/c1-19(2)10-9-13-36(8,45-31-29(43)28(42)27(41)23(18-37)44-31)20-11-15-34(6)26(20)21(38)16-24-33(5)14-12-25(40)32(3,4)30(33)22(39)17-35(24,34)7/h10,20-31,37-43H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24+,25-,26-,27+,28-,29+,30-,31-,33+,34+,35+,36-/m0/s1
SMILES Code
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]4(C)C[C@H](O)[C@]5([H])[C@@](CC[C@H](O)C5(C)C)(C)[C@@]4([H])C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 638.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang JH, Wang D, Li WX, Huang Y, Dai ZB, Zhang XL. [Optimization of UDP- glucose supply module and production of ginsenoside F1 in Saccharomyces cerevisiae]. Zhongguo Zhong Yao Za Zhi. 2019 Nov;44(21):4596-4604. Chinese. doi: 10.19540/j.cnki.cjcmm.20190829.101. PMID: 31872653. 2: Han J, Oh JP, Yoo M, Cui CH, Jeon BM, Kim SC, Han JH. Minor ginsenoside F1 improves memory in APP/PS1 mice. Mol Brain. 2019 Sep 5;12(1):77. doi: 10.1186/s13041-019-0495-7. PMID: 31488185; PMCID: PMC6728944. 3: Cui CH, Jeon BM, Fu Y, Im WT, Kim SC. High-density immobilization of a ginsenoside-transforming β-glucosidase for enhanced food-grade production of minor ginsenosides. Appl Microbiol Biotechnol. 2019 Sep;103(17):7003-7015. doi: 10.1007/s00253-019-09951-4. Epub 2019 Jul 9. PMID: 31289903; PMCID: PMC6690934. 4: Zhang J, Liu M, Huang M, Chen M, Zhang D, Luo L, Ye G, Deng L, Peng Y, Wu X, Liu G, Ye W, Zhang D. Ginsenoside F1 promotes angiogenesis by activating the IGF-1/IGF1R pathway. Pharmacol Res. 2019 Jun;144:292-305. doi: 10.1016/j.phrs.2019.04.021. Epub 2019 Apr 29. PMID: 31048033. 5: Lee CS, Nam G, Bae IH, Park J. Whitening efficacy of ginsenoside F1 through inhibition of melanin transfer in cocultured human melanocytes-keratinocytes and three-dimensional human skin equivalent. J Ginseng Res. 2019 Apr;43(2):300-304. doi: 10.1016/j.jgr.2017.12.005. Epub 2018 Jan 31. PMID: 30962737; PMCID: PMC6437421. 6: Guo YP, Chen MY, Shao L, Zhang W, Rao T, Zhou HH, Huang WH. Quantification of Panax notoginseng saponins metabolites in rat plasma with in vivo gut microbiota-mediated biotransformation by HPLC-MS/MS. Chin J Nat Med. 2019 Mar;17(3):231-240. doi: 10.1016/S1875-5364(19)30026-3. PMID: 30910060. 7: Kang JI, Choi Y, Cui CH, Lee D, Kim SC, Kim HM. Pro-angiogenic Ginsenosides F1 and Rh1 Inhibit Vascular Leakage by Modulating NR4A1. Sci Rep. 2019 Mar 14;9(1):4502. doi: 10.1038/s41598-019-41115-2. PMID: 30872732; PMCID: PMC6418182. 8: Noh HY, Lu J, Hanif Siddiqi M, Natatajan S, Kang S, Ahn S, Kim YJ, Yang DC. Computational Investigation of Ginsenoside F1 from Panax ginseng Meyer as p38 MAP Kinase Inhibitor: Molecular Docking and Dynamics Simulations, ADMET Analysis, and Drug Likeness Prediction. Iran J Pharm Res. 2018 Fall;17(4):1318-1327. PMID: 30568690; PMCID: PMC6269553. 9: Kwon HJ, Lee H, Choi GE, Kwon SJ, Song AY, Kim SJ, Choi WS, Hwang SH, Kim SC, Kim HS. Ginsenoside F1 Promotes Cytotoxic Activity of NK Cells via Insulin-Like Growth Factor-1-Dependent Mechanism. Front Immunol. 2018 Nov 28;9:2785. doi: 10.3389/fimmu.2018.02785. PMID: 30546365; PMCID: PMC6279892. 10: Moon SS, Lee HJ, Mathiyalagan R, Kim YJ, Yang DU, Lee DY, Min JW, Jimenez Z, Yang DC. Synthesis of a Novel α-Glucosyl Ginsenoside F1 by Cyclodextrin Glucanotransferase and Its In Vitro Cosmetic Applications. Biomolecules. 2018 Nov 10;8(4):142. doi: 10.3390/biom8040142. PMID: 30423825; PMCID: PMC6315644. 11: Wang XJ, Zhang AH, Kong L, Yu JB, Gao HL, Liu ZD, Sun H. Rapid discovery of quality-markers from Kaixin San using chinmedomics analysis approach. Phytomedicine. 2019 Feb 15;54:371-381. doi: 10.1016/j.phymed.2017.12.014. Epub 2017 Dec 18. PMID: 30322673. 12: Zhang AH, Yu JB, Sun H, Kong L, Wang XQ, Zhang QY, Wang XJ. Identifying quality-markers from Shengmai San protects against transgenic mouse model of Alzheimer's disease using chinmedomics approach. Phytomedicine. 2018 Jun 1;45:84-92. doi: 10.1016/j.phymed.2018.04.004. Epub 2018 Apr 3. PMID: 29685366. 13: Hou J, Cui C, Kim S, Sung C, Choi C. Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype. Chem Biol Interact. 2018 Mar 1;283:75-83. doi: 10.1016/j.cbi.2018.02.002. Epub 2018 Feb 3. PMID: 29412148. 14: Wang DD, Jin Y, Wang C, Kim YJ, Perez ZEJ, Baek NI, Mathiyalagan R, Markus J, Yang DC. Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from Bacillus subtilis: synthesis, characterization, and in vitro melanogenesis inhibition activity in BL6B16 cells. J Ginseng Res. 2018 Jan;42(1):42-49. doi: 10.1016/j.jgr.2016.12.009. Epub 2016 Dec 24. PMID: 29348721; PMCID: PMC5766694. 15: Qin M, Luo Y, Lu S, Sun J, Yang K, Sun G, Sun X. Ginsenoside F1 Ameliorates Endothelial Cell Inflammatory Injury and Prevents Atherosclerosis in Mice through A20-Mediated Suppression of NF-kB Signaling. Front Pharmacol. 2017 Dec 22;8:953. doi: 10.3389/fphar.2017.00953. PMID: 29311947; PMCID: PMC5744080. 16: Feng WH, Li C, Ji LN, Yang LX, Rong LX, Chen LM, Yi H, Wang ZM. [Study on UPLC fingerprint of red ginseng based on good separation and good purity of chromatographic peaks]. Zhongguo Zhong Yao Za Zhi. 2016 Oct;41(20):3798-3804. Chinese. doi: 10.4268/cjcmm20162015. PMID: 28929658. 17: An DS, Cui CH, Siddiqi MZ, Yu HS, Jin FX, Kim SG, Im WT. Gram-Scale Production of Ginsenoside F1 Using a Recombinant Bacterial β-Glucosidase. J Microbiol Biotechnol. 2017 Sep 28;27(9):1559-1565. doi: 10.4014/jmb.1703.03006. PMID: 28633513. 18: Wang Y, Choi KD, Yu H, Jin F, Im WT. Production of ginsenoside F1 using commercial enzyme Cellulase KN. J Ginseng Res. 2016 Apr;40(2):121-6. doi: 10.1016/j.jgr.2015.06.003. Epub 2015 Jun 19. PMID: 27158232; PMCID: PMC4845047. 19: Wang Y, Liang X, Chen Y, Zhao X. Screening SIRT1 Activators from Medicinal Plants as Bioactive Compounds against Oxidative Damage in Mitochondrial Function. Oxid Med Cell Longev. 2016;2016:4206392. doi: 10.1155/2016/4206392. Epub 2016 Feb 11. PMID: 26981165; PMCID: PMC4766345. 20: Wei W, Wang P, Wei Y, Liu Q, Yang C, Zhao G, Yue J, Yan X, Zhou Z. Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts. Mol Plant. 2015 Sep;8(9):1412-24. doi: 10.1016/j.molp.2015.05.010. Epub 2015 May 30. PMID: 26032089.

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