Synonym
Carbuterol (free base); EINECS252-257-5; EINECS-252-257-5; EINECS 252-257-5
IUPAC/Chemical Name
1-(5-(2-(tert-butylamino)-1-hydroxyethyl)-2-hydroxyphenyl)urea
InChi Key
KEMXXQOFIRIICG-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H21N3O3/c1-13(2,3)15-7-11(18)8-4-5-10(17)9(6-8)16-12(14)19/h4-6,11,15,17-18H,7H2,1-3H3,(H3,14,16,19)
SMILES Code
CC(C)(NCC(c1cc(NC(N)=O)c(O)cc1)O)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
267.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA. Metabolic and cardiovascular effects of carbuterol and metaproterenol. J Allergy Clin Immunol. 1977 Sep;60(3):174-9. doi: 10.1016/0091-6749(77)90121-x. PMID: 19514.
2: Misra NP, Tiwari UC, Khemchandani GT. Double-blind crossover study of carbuterol and salbutamol in bronchial asthma. J Int Med Res. 1981;9(4):261-7. doi: 10.1177/030006058100900405. PMID: 6114884.
3: Beumer HM, Mills JG, Sharpe PC. Comparative study of carbuterol and salbutamol from metered aerosols in bronchial asthma. Respiration. 1978;35(4):220-3. doi: 10.1159/000193882. PMID: 345380.
4: Minette A, Marcq M, Gepts L. Carbuterol, fenoterol, orciprenaline, salbutamol and terbutaline per os in reversible obstructive chronic bronchitis. Bull Eur Physiopathol Respir. 1976 Jul-Aug;12(4):545-53. PMID: 13895.
5: Tabas A, Rodríguez A, Lobera T, Diéguez I, Oehling A. Carbuterol, salbutamol and DSCG in exercise-induced asthma. Allergol Immunopathol (Madr). 1985 Nov- Dec;13(6):493-500. PMID: 3938615.
6: Colella DF, Chakrin LW, Shetzline A, Wardell JR Jr. Characterization of the adrenergic activity of carbuterol (SK&F 40383-A). Eur J Pharmacol. 1977 Dec 1;46(3):229-41. doi: 10.1016/0014-2999(77)90338-7. PMID: 22441.
7: Rhoades RB, Leifer KN, Bloom FL, Wittig HJ. Spirometric comparison of carbuterol and isoproterenol aerosol therapy in bronchial asthma. A double blind, matched-pair study of 28 adults and a double blind crossover study of 18 children. Am Rev Respir Dis. 1976 Jul;114(1):79-86. doi: 10.1164/arrd.1976.114.1.79. PMID: 7174.
8: James TD, Lyons HA. A comparative study of bronchodilator effects of carbuterol and ephedrine. JAMA. 1979 Feb 16;241(7):704-5. PMID: 368368.
9: Irsigler GB, Ker J. Comparison of carbuterol and hexoprenaline aerosol in bronchial asthma. S Afr Med J. 1978 Apr 15;53(15):571-3. PMID: 354041.
10: Funahashi A, Hamilton LH. A study of a new bronchodilator: carbuterol. Am Rev Respir Dis. 1976 Mar;113(3):398-40. doi: 10.1164/arrd.1976.113.3.398. PMID: 1259244.
