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MedKoo Cat#: 574969 | Name: Aprindine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aprindine is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias.

Chemical Structure

Aprindine
CAS#37640-71-4 (free base)

Theoretical Analysis

MedKoo Cat#: 574969

Name: Aprindine

CAS#: 37640-71-4 (free base)

Chemical Formula: C22H30N2

Exact Mass: 322.2409

Molecular Weight: 322.49

Elemental Analysis: C, 81.94; H, 9.38; N, 8.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
33237-74-0 (HCl) 37640-71-4 (free base)
Synonym
AC 1802; AC-1802; AC1802; Aprindine; Compound 99170
IUPAC/Chemical Name
N,N-Diethyl-N'-2-indanyl-N'-phenyl-1,3-propanediamine
InChi Key
NZLBHDRPUJLHCE-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3
SMILES Code
CCN(CC)CCCN(C1Cc2ccccc2C1)c3ccccc3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 322.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ozawa M, Komatsu T, Sato Y, Kunugita F, Tachibana H, Tashiro A, Okabayashi H, Nakamura M. Comparison of the effects of bepridil and aprindine for the prevention of atrial fibrillation after cardiac and aortic surgery: A prospective randomized study. J Arrhythm. 2015 Oct;31(5):302-6. doi: 10.1016/j.joa.2015.04.003. Epub 2015 May 16. PubMed PMID: 26550087; PubMed Central PMCID: PMC4600894. 2: Nakatani Y, Sakamoto T, Nishida K, Kataoka N, Yamaguchi Y, Sakabe M, Fujiki A, Mizumaki K, Inoue H. Bepridil enhances aprindine-induced prolongation of atrial effective refractory period in a canine atrial rapid pacing model. J Cardiol. 2015 Nov;66(5):445-50. doi: 10.1016/j.jjcc.2015.06.001. Epub 2015 Jul 7. PubMed PMID: 26162947. 3: Tsuchishita Y, Fukumoto K, Kusumoto M, Ueno K. Relationship between serum aprindine concentration and neurologic side effects in Japanese. Biol Pharm Bull. 2009 Apr;32(4):637-9. PubMed PMID: 19336897.