Hexcarbacholine (free base) is a long-acting muscle-relaxant drug that had been used extensively in Europe in surgical anesthesia, but had had considerably less clinical usage in US. There is no precise agreement concerning the mode of action of hexacarbacholine at the myoneural junction. Therapeutic doses of the drug do not appear to influence the cardiovascular system, cardiac activity, or blood pressure, although large doses do cause slight and transient increases in blood pressure in laboratory animals. The intraocular tension in man is increased temporarily following the administration of hexacarbacholine. Since hexacarbacholine is a cumulative drug, repeated administrations should be avoided. It may cause cardiac arrest due to a hyperkalaemia.
MedKoo Cat#: 412316
Name: Hexcarbacholine (free base)
CAS#: 13309-41-6 (free base)
Chemical Formula: C18H40N4O42+
Exact Mass: 376.3039
Molecular Weight: 376.54
Elemental Analysis: C, 57.42; H, 10.71; N, 14.88; O, 17.00
The following data is based on the product molecular weight 376.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
