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MedKoo Cat#: 463271 | Name: ARS-1323-Alkyne
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ARS-1323-Alkyne is a novel KRASG12C occupancy probe.

Chemical Structure

ARS-1323-Alkyne
ARS-1323-Alkyne
CAS#2436544-27-1

Theoretical Analysis

MedKoo Cat#: 463271

Name: ARS-1323-Alkyne

CAS#: 2436544-27-1

Chemical Formula: C28H27ClF2N6O3

Exact Mass: 568.1801

Molecular Weight: 569.01

Elemental Analysis: C, 59.10; H, 4.78; Cl, 6.23; F, 6.68; N, 14.77; O, 8.44

Price and Availability

Size Price Availability Quantity
25mg USD 2,250.00 2 Weeks
50mg USD 3,250.00 2 Weeks
100mg USD 5,450.00 2 Weeks
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Related CAS #
No Data
Synonym
ARS-1323-Alkyne; ARS1323-Alkyne; ARS 1323-Alkyne; ARS-1323 Alkyne;
IUPAC/Chemical Name
3-((4-(4-acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-2-yl)amino)-N-methyl-N-(prop-2-yn-1-yl)propanamide
InChi Key
FCCFZQSNDSLLMI-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H27ClF2N6O3/c1-4-11-35(3)22(40)9-10-32-28-33-26-17(27(34-28)37-14-12-36(13-15-37)21(39)5-2)16-18(29)23(25(26)31)24-19(30)7-6-8-20(24)38/h1,5-8,16,38H,2,9-15H2,3H3,(H,32,33,34)
SMILES Code
O=C(N(C)CC#C)CCNC1=NC(N2CCN(C(C=C)=O)CC2)=C3C=C(Cl)C(C4=C(O)C=CC=C4F)=C(F)C3=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 569.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Lou K, Steri V, Ge AY, Hwang YC, Yogodzinski CH, Shkedi AR, Choi ALM, Mitchell DC, Swaney DL, Hann B, Gordan JD, Shokat KM, Gilbert LA. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583):eaaw9450. doi: 10.1126/scisignal.aaw9450. PMID: 31138768; PMCID: PMC6871662.

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