MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 558503 | Name: Trichlorfon
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trichlorfon is organophosphorous pesticide and among the most commonly used products to treat fish parasites in aquaculture. It is also used in anthelmintic compositions for animals.

Chemical Structure

Trichlorfon
Trichlorfon
CAS#52-68-6

Theoretical Analysis

MedKoo Cat#: 558503

Name: Trichlorfon

CAS#: 52-68-6

Chemical Formula: C4H8Cl3O4P

Exact Mass: 255.9200

Molecular Weight: 257.43

Elemental Analysis: C, 18.66; H, 3.13; Cl, 41.31; O, 24.86; P, 12.03

Price and Availability

Size Price Availability Quantity
50mg USD 350.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Trichlorfon; Masoten; Mazoten; Methyl chlorophos; Metrifonate; Metrifonato;
IUPAC/Chemical Name
Dimethyl(2,2,2-trichloro-1-hydroxyethyl)phosphonate
InChi Key
NFACJZMKEDPNKN-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3
SMILES Code
OC(P(OC)(OC)=O)C(Cl)(Cl)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 257.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yonar ME, Yonar SM, Pala A, Silici S, Sağlam N. Trichlorfon-induced haematological and biochemical changes in Cyprinus carpio: ameliorative effect of propolis. Dis Aquat Organ. 2015 Jun 3;114(3):209-16. doi: 10.3354/dao02866. PubMed PMID: 26036828. 2: Venturini FP, Moraes FD, Cortella LR, Rossi PA, Cruz C, Moraes G. Metabolic effects of trichlorfon (Masoten®) on the neotropical freshwater fish pacu (Piaractus mesopotamicus). Fish Physiol Biochem. 2015 Feb;41(1):299-309. doi: 10.1007/s10695-014-9983-y. Epub 2014 Sep 6. PubMed PMID: 25192665. 3: Zhao T, Wang Q, Li J, Qiao X, Xu Z. Study on an electrochromatography method based on organic-inorganic hybrid molecularly imprinted monolith for determination of trace trichlorfon in vegetables. J Sci Food Agric. 2014 Aug;94(10):1974-80. doi: 10.1002/jsfa.6511. Epub 2014 Jan 2. PubMed PMID: 24323896. 4: Jiang K, Zhang N, Zhang H, Wang J, Qian M. Investigation on the Gas-phase decomposition of trichlorfon by GC-MS and theoretical calculation. PLoS One. 2015 Apr 9;10(4):e0121389. doi: 10.1371/journal.pone.0121389. eCollection 2015. PubMed PMID: 25856549; PubMed Central PMCID: PMC4391870. 5: Chen XJ, Ren YJ, Meng ZY, Lu CL, Gu HT, Zhuang YQ. Dissipation kinetics, safety evaluation, and preharvest interval assessment of trichlorfon application on rice. Environ Monit Assess. 2016 May;188(5):266. doi: 10.1007/s10661-016-5264-9. Epub 2016 Apr 5. PubMed PMID: 27048491. 6: Xu W, Liu W, Shao X, Jiang G, Li X. Effect of trichlorfon on hepatic lipid accumulation in crucian carp Carassius auratus gibelio. J Aquat Anim Health. 2012 Sep;24(3):185-94. doi: 10.1080/08997659.2012.675937. PubMed PMID: 22897202; PubMed Central PMCID: PMC3464453. 7: Tian J, Dong Q, Yu C, Zhao R, Wang J, Chen L. Biodegradation of the Organophosphate Trichlorfon and Its Major Degradation Products by a Novel Aspergillus sydowii PA F-2. J Agric Food Chem. 2016 Jun 1;64(21):4280-7. doi: 10.1021/acs.jafc.6b00909. Epub 2016 May 17. PubMed PMID: 27161040. 8: Tian J, Yu C, Xue Y, Zhao R, Wang J, Chen L. Performance of trichlorfon degradation by a novel Bacillus tequilensis strain PA F-3 and its proposed biodegradation pathway. Biodegradation. 2016 Nov;27(4-6):265-276. Epub 2016 Sep 8. PubMed PMID: 27632165. 9: Wang GM, Dai H, Li YG, Li XL, Zhang JZ, Zhang L, Fu YY, Li ZG. Simultaneous determination of residues of trichlorfon and dichlorvos in animal tissues by LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Jul;27(7):983-8. doi: 10.1080/19440041003671270. PubMed PMID: 20432099. 10: Li W, Ma Y, Li L, Qin DM, Wu YJ. The dissipation rates of trichlorfon and its degradation product dichlorvos in cabbage and soil. Chemosphere. 2011 Feb;82(6):829-33. doi: 10.1016/j.chemosphere.2010.11.027. Epub 2010 Dec 4. PubMed PMID: 21134689. 11: Chen H, Jiang JG. Toxic effects of chemical pesticides (trichlorfon and dimehypo) on Dunaliella salina. Chemosphere. 2011 Jul;84(5):664-70. doi: 10.1016/j.chemosphere.2011.03.032. Epub 2011 May 28. PubMed PMID: 21621243. 12: Pohanka M, Jun D, Kuca K. In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048. J Enzyme Inhib Med Chem. 2009 Jun;24(3):680-3. doi: 10.1080/14756360802328315. PubMed PMID: 18825528. 13: Lopes WD, dos Santos TR, Borges Fde A, Sakamoto CA, Soares VE, Costa GH, Camargo G, Pulga ME, Bhushan C, da Costa AJ. Anthelmintic efficacy of oral trichlorfon solution against ivermectin resistant nematode strains in cattle. Vet Parasitol. 2009 Dec 3;166(1-2):98-102. doi: 10.1016/j.vetpar.2009.07.045. Epub 2009 Aug 5. PubMed PMID: 19709817. 14: Tian Y, Dai F, Shen L, Feng Y, Gao Y, Xu L, Han S, Shen X. The effects of trichlorfon on maternal reproduction and mouse embryo development during organogenesis. Ind Health. 2009 Jul;47(3):313-8. PubMed PMID: 19531917. 15: Mataqueiro MI, Nakaghi LS, Yamada PK, de Camargo Ferraz G, de Queiroz-Neto A, DeOliveira GH. Degradation, residual determination, and cholinesterase activity of triclorfon in Piaractus mesopotamicus Holmberg (PACU) 1887. J Toxicol Environ Health A. 2014;77(1-3):125-32. doi: 10.1080/15287394.2013.866928. PubMed PMID: 24555653. 16: Mehl A, Schanke TM, Johnsen BA, Fonnum F. The effect of trichlorfon and other organophosphates on prenatal brain development in the guinea pig. Neurochem Res. 1994 May;19(5):569-74. PubMed PMID: 8065512. 17: Wu L, Green RL, Liu G, Yates MV, Pacheco P, Gan J, Yates SR. Partitioning and persistence of trichlorfon and chlorpyrifos in a creeping bentgrass putting green. J Environ Qual. 2002 May-Jun;31(3):889-95. PubMed PMID: 12026092. 18: Bao Y, Zhang C, Yang W, Hu J, Sun X. Mechanism and kinetics study on the OH-initiated oxidation of organophosphorus pesticide trichlorfon in atmosphere. Sci Total Environ. 2012 Mar 1;419:144-50. doi: 10.1016/j.scitotenv.2012.01.004. Epub 2012 Jan 29. PubMed PMID: 22289171. 19: Lopes RB, Paraiba LC, Ceccarelli PS, Tornisielo VL. Bioconcentration of trichlorfon insecticide in pacu (Piaractus mesopotamicus). Chemosphere. 2006 Jun;64(1):56-62. Epub 2006 Jan 6. PubMed PMID: 16405959. 20: Drudge JH, Lyons ET, Taylor EL. Critical tests and safety studies on trichlorfon as an antiparasitic agent in the horse. Am J Vet Res. 1976 Feb;37(2):139-44. PubMed PMID: 1259212.