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MedKoo Cat#: 412240 | Name: Meclozine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Meclozine is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

Chemical Structure

Meclozine
Meclozine
CAS#569-65-3 (free base)

Theoretical Analysis

MedKoo Cat#: 412240

Name: Meclozine

CAS#: 569-65-3 (free base)

Chemical Formula: C25H27ClN2

Exact Mass: 390.1863

Molecular Weight: 390.96

Elemental Analysis: C, 76.81; H, 6.96; Cl, 9.07; N, 7.17

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Related CAS #
1104-22-9 (2HCl) 569-65-3 (free base) 31884-77-2 (HCl hydrate) 36236-67-6 (HCl)
Synonym
Meclozine; HSDB3113; HSDB-3113; HSDB 3113; Meclizine
IUPAC/Chemical Name
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-
InChi Key
OCJYIGYOJCODJL-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3
SMILES Code
CC1=CC(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Meclozine is a histamine H1 antagonist.
In vitro activity:
In Vitro, meclozine reduced the production of CXCL8/IL-8 and IL-1β mRNA and protein by C. acnes-stimulated human keratinocytes and monocytes. Meclozine prevented the phosphorylation of ERK and JNK. Reference: Biomedicines. 2022 Apr 19;10(5):931. https://pubmed.ncbi.nlm.nih.gov/35625668/
In vivo activity:
Meclozine was administered orally to 7-day-old Hyp mice for 10 days, after which the mice were subjected to blood sampling and histological analyses of the first coccygeal vertebra, femur and tibia. Meclozine treatment improved the abnormally thick hypertrophic zone of the growth plate and ameliorated the downregulation of osteoclast surface/bone surface in Hyp mice. However, meclozine had only a marginal effect on mineralization in the trabecular bone and on calcium and phosphate plasma levels. Reference: Exp Ther Med. 2022 Nov 30;25(1):39. https://pubmed.ncbi.nlm.nih.gov/36569439/

Preparing Stock Solutions

The following data is based on the product molecular weight 390.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Grange PA, Ollagnier G, Beauvais Remigereau L, Nicco C, Mayslich C, Marcelin AG, Calvez V, Dupin N. A New Topical Candidate in Acne Treatment: Characterization of the Meclozine Hydrochloride as an Anti-Inflammatory Compound from In Vitro to a Preliminary Clinical Study. Biomedicines. 2022 Apr 19;10(5):931. doi: 10.3390/biomedicines10050931. PMID: 35625668; PMCID: PMC9138413. 2. Liu P, Hu D, Yuan L, Lian Z, Yao X, Zhu Z, Nowotny N, Shi Y, Li X. Meclizine Inhibits Pseudorabies Virus Replication by Interfering With Virus Entry and Release. Front Microbiol. 2021 Dec 22;12:795593. doi: 10.3389/fmicb.2021.795593. PMID: 35003025; PMCID: PMC8727530. 3. Kamiya Y, Matsushita M, Mishima K, Ohkawara B, Michigami T, Imagama S, Ohno K, Kitoh H. Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X‑linked hypophosphatemia. Exp Ther Med. 2022 Nov 30;25(1):39. doi: 10.3892/etm.2022.11738. PMID: 36569439; PMCID: PMC9764053. 4. Jang EH, Bae HD, Jeon Y, Shin DH, Kang S, Lee K. Meclizine, a piperazine-derivative antihistamine, binds to dimerized translationally controlled tumor protein and attenuates allergic reactions in a mouse model. Biomed Pharmacother. 2023 Jan;157:114072. doi: 10.1016/j.biopha.2022.114072. Epub 2022 Dec 6. PMID: 36493627.
In vitro protocol:
1. Grange PA, Ollagnier G, Beauvais Remigereau L, Nicco C, Mayslich C, Marcelin AG, Calvez V, Dupin N. A New Topical Candidate in Acne Treatment: Characterization of the Meclozine Hydrochloride as an Anti-Inflammatory Compound from In Vitro to a Preliminary Clinical Study. Biomedicines. 2022 Apr 19;10(5):931. doi: 10.3390/biomedicines10050931. PMID: 35625668; PMCID: PMC9138413. 2. Liu P, Hu D, Yuan L, Lian Z, Yao X, Zhu Z, Nowotny N, Shi Y, Li X. Meclizine Inhibits Pseudorabies Virus Replication by Interfering With Virus Entry and Release. Front Microbiol. 2021 Dec 22;12:795593. doi: 10.3389/fmicb.2021.795593. PMID: 35003025; PMCID: PMC8727530.
In vivo protocol:
1. Kamiya Y, Matsushita M, Mishima K, Ohkawara B, Michigami T, Imagama S, Ohno K, Kitoh H. Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X‑linked hypophosphatemia. Exp Ther Med. 2022 Nov 30;25(1):39. doi: 10.3892/etm.2022.11738. PMID: 36569439; PMCID: PMC9764053. 2. Jang EH, Bae HD, Jeon Y, Shin DH, Kang S, Lee K. Meclizine, a piperazine-derivative antihistamine, binds to dimerized translationally controlled tumor protein and attenuates allergic reactions in a mouse model. Biomed Pharmacother. 2023 Jan;157:114072. doi: 10.1016/j.biopha.2022.114072. Epub 2022 Dec 6. PMID: 36493627.