Synonym
E 4695; E4695; E-4695;
IUPAC/Chemical Name
7-((2S,3R)-3-amino-2-methylazetidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
InChi Key
AUJKWLGOXRSXRX-JVXZTZIISA-N
InChi Code
InChI=1S/C16H17FN4O3/c1-7-12(18)6-20(7)15-11(17)4-9-13(22)10(16(23)24)5-21(8-2-3-8)14(9)19-15/h4-5,7-8,12H,2-3,6,18H2,1H3,(H,23,24)/t7-,12+/m0/s1
SMILES Code
C[C@H]1[C@@H](CN1c2c(F)cc3c(N(C4CC4)C=C(C3=O)C(O)=O)n2)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
332.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Guinea J, Gargallo-Viola D, Robert M, Tudela E, Xicota MA, Garcia J, Esteve M, Coll R, Pares M, Roser R. E-4695, a new C-7 azetidinyl fluoronaphthyridine with enhanced activity against gram-positive and anaerobic pathogens. Antimicrob Agents Chemother. 1995 Feb;39(2):413-21. doi: 10.1128/aac.39.2.413. PMID: 7726507; PMCID: PMC162552.
2: Mirelis B, Miró E, Navarro F, Prats G. In-vitro activity of E-4695, a new fluoronaphthyridine antimicrobial agent. J Antimicrob Chemother. 1994 May;33(5):1017-23. doi: 10.1093/jac/33.5.1017. PMID: 8089047.
3: Gooding BB, Erwin ME, Barrett MS, Johnson DM, Jones RN. Antimicrobial activities of two investigational fluoroquinolones (CI-960 and E4695) against over 100 Legionella sp. isolates. Antimicrob Agents Chemother. 1992 Sep;36(9):2049-50. doi: 10.1128/aac.36.9.2049. PMID: 1329642; PMCID: PMC192436.
4: Jones RN. In vitro evaluation of E-4695, a new fluoro-naphthyridine. Eur J Clin Microbiol Infect Dis. 1992 Feb;11(2):188-94. doi: 10.1007/BF01967076. PMID: 1327787.
