Synonym
NE 21610; NE21610; NE-21610
IUPAC/Chemical Name
9-Octadecenamide, N-((4-(2-aminoethoxy)-3-methoxyphenyl)methyl)-, (Z)-
InChi Key
BTKHXNIRAYKGMN-KHPPLWFESA-N
InChi Code
InChI=1S/C28H48N2O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-28(31)30-24-25-19-20-26(33-22-21-29)27(23-25)32-2/h10-11,19-20,23H,3-9,12-18,21-22,24,29H2,1-2H3,(H,30,31)/b11-10-
SMILES Code
CCCCCCCC/C=C\CCCCCCCC(NCC1=CC=C(OCCN)C(OC)=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
460.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Davis KD, Meyer RA, Turnquist JL, Filloon TG, Pappagallo M, Campbell JN. Cutaneous pretreatment with the capsaicin analog NE-21610 prevents the pain to a burn and subsequent hyperalgesia. Pain. 1995 Sep;62(3):373-8. doi: 10.1016/0304-3959(95)00007-f. PMID: 8657438.
2: Davis KD, Meyer RA, Turnquist JL, Filloon TG, Pappagallo M, Campbell JN. Cutaneous injection of the capsaicin analogue, NE-21610, produces analgesia to heat but not to mechanical stimuli in man. Pain. 1995 Apr;61(1):17-26. doi: 10.1016/0304-3959(94)00154-7. PMID: 7644243.
3: Dray A, Bettaney J, Rueff A, Walpole C, Wrigglesworth R. NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro. Eur J Pharmacol. 1990 Jun 8;181(3):289-93. doi: 10.1016/0014-2999(90)90091-j. PMID: 2384136.
4: Kasting GB, Francis WR, Bowman LA, Kinnett GO. Percutaneous absorption of vanilloids: in vivo and in vitro studies. J Pharm Sci. 1997 Jan;86(1):142-6. doi: 10.1021/js950484a. PMID: 9002474.
5: Pini A, Lynn B. C-fibre Function During the 6 Weeks Following Brief Application of Capsaicin to a Cutaneous Nerve in the Rat. Eur J Neurosci. 1991;3(3):274-284. doi: 10.1111/j.1460-9568.1991.tb00089.x. PMID: 12106205.
